Piperazine-1,4-diylbis[(2-chlorophenyl)methanone]

Base Information

• Chemical Name: Piperazine-1,4-diylbis[(2-chlorophenyl)methanone]
• CAS No.: 13754-35-3
• Molecular Formula: C₁₈H₁₆Cl₂N₂O₂
• Molecular Weight: 363.243
• NSC Number: 89458
• DSSTox Substance ID: DTXSID00293430
• Wikidata: Q82032152
• Mol file: 13754-35-3.mol

Synonyms:13754-35-3;Piperazine, 1,4-bis(2-chlorobenzoyl)- (9CI);piperazine-1,4-diylbis[(2-chlorophenyl)methanone];NSC89458;NCIOpen2_009608;Oprea1_641675;Oprea1_701118;SCHEMBL10723816;DTXSID00293430;1,4-bis(2-chlorobenzoyl)piperazine;NSC-89458;AKOS000595709;CCG-311107;Z52115539

Chemical Property of Piperazine-1,4-diylbis[(2-chlorophenyl)methanone]

Chemical Property:

• Vapor Pressure: 1.1E-12mmHg at 25°C
• Boiling Point: 562.6°Cat760mmHg
• Flash Point: 294.1°C
• Density: 1.362g/cm³
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 362.0588831
• Heavy Atom Count: 24
• Complexity: 424

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1C(=O)C2=CC=CC=C2Cl)C(=O)C3=CC=CC=C3Cl

Technology Process of Piperazine-1,4-diylbis[(2-chlorophenyl)methanone]

There total 2 articles about Piperazine-1,4-diylbis[(2-chlorophenyl)methanone] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine (110-85-0) + o-chlorobenzoyl chloride (609-65-4) → 1,4-bis-(2-chloro-benzoyl)-piperazine (13754-35-3)

Guidance literature:

With sodium carbonate; isopropyl alcohol;

DOI:10.1021/ja01098a511

Reference yield:

→ 1,4-bis-(2-chloro-benzoyl)-piperazine (13754-35-3)

Guidance literature:

Piperazin, o-Chlor-benzoylchlorid;

DOI:10.1021/jm00310a022

upstream raw materials:

piperazine

o-chlorobenzoyl chloride