Benzoic acid, 2-[4-[[2-butyl-4-chloro-5-[[(methoxycarbonyl)amino]methyl]-1H-imidazol- 1-yl]methyl]benzoyl]-, methyl ester

Base Information

Chemical Name:Benzoic acid, 2-[4-[[2-butyl-4-chloro-5-[[(methoxycarbonyl)amino]methyl]-1H-imidazol- 1-yl]methyl]benzoyl]-, methyl ester
CAS No.:114773-04-5
Molecular Formula:C26H28ClN3O5
Molecular Weight:497.978
Hs Code.:
Mol file:114773-04-5.mol

Synonyms:

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Chemical Property of Benzoic acid, 2-[4-[[2-butyl-4-chloro-5-[[(methoxycarbonyl)amino]methyl]-1H-imidazol- 1-yl]methyl]benzoyl]-, methyl ester

Chemical Property:

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Technology Process of Benzoic acid, 2-[4-[[2-butyl-4-chloro-5-[[(methoxycarbonyl)amino]methyl]-1H-imidazol- 1-yl]methyl]benzoyl]-, methyl ester

There total 6 articles about Benzoic acid, 2-[4-[[2-butyl-4-chloro-5-[[(methoxycarbonyl)amino]methyl]-1H-imidazol- 1-yl]methyl]benzoyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114773-94-3
2-[4-(5-Aminomethyl-2-butyl-4-chloro-imidazol-1-ylmethyl)-benzoyl]-benzoic acid methyl ester

: 79-22-1
methyl chloroformate

: 114773-04-5
2-butyl-1-<4-(carbomethoxybenzoyl)benzyl>-4-chloro-5-<<(methoxycarbonyl)amino>methyl>imidazole

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 25 ℃; for 4h; Yield given;
DOI:10.1021/jm00167a008

Reference yield:

: 6424-25-5
methyl 2-(4-methylbenzoyl)benzoate

: 114773-04-5
2-butyl-1-<4-(carbomethoxybenzoyl)benzyl>-4-chloro-5-<<(methoxycarbonyl)amino>methyl>imidazole

Guidance literature:: Multi-step reaction with 6 steps

1: N-bromosuccinimide, azobisisobutyronitrile / CCl₄ / 3 h / Heating

2: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) 40 deg C, 4 h

3: thionyl chloride / CHCl₃ / 4 h / 25 °C

4: 63 percent / sodium azide / dimethylsulfoxide / 5 h / 25 °C

5: 2.92 g / chromium(II) chloride / acetone; H₂O / 25 °C

6: NaOH / tetrahydrofuran; H₂O / 4 h / 25 °C

With chromium dichloride; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; sodium azide; 2,2'-azobis(isobutyronitrile); sodium methylate; In tetrahydrofuran; tetrachloromethane; chloroform; water; dimethyl sulfoxide; acetone;
DOI:10.1021/jm00167a008

Reference yield:

: 114772-96-2
methyl 2-[4-(bromomethyl)benzoyl]benzoate

: 114773-04-5
2-butyl-1-<4-(carbomethoxybenzoyl)benzyl>-4-chloro-5-<<(methoxycarbonyl)amino>methyl>imidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) 40 deg C, 4 h

2: thionyl chloride / CHCl₃ / 4 h / 25 °C

3: 63 percent / sodium azide / dimethylsulfoxide / 5 h / 25 °C

4: 2.92 g / chromium(II) chloride / acetone; H₂O / 25 °C

5: NaOH / tetrahydrofuran; H₂O / 4 h / 25 °C

With chromium dichloride; sodium hydroxide; thionyl chloride; sodium azide; sodium methylate; In tetrahydrofuran; chloroform; water; dimethyl sulfoxide; acetone;
DOI:10.1021/jm00167a008