1H-Imidazole-5-acetic acid, 2-butyl-4-chloro-1-[[4-[[2-[[(trifluoromethyl)sulfonyl]amino]benzoyl]amino] phenyl]methyl]-, methyl ester

Base Information

Chemical Name:1H-Imidazole-5-acetic acid, 2-butyl-4-chloro-1-[[4-[[2-[[(trifluoromethyl)sulfonyl]amino]benzoyl]amino] phenyl]methyl]-, methyl ester
CAS No.:114798-59-3
Molecular Formula:C25H26ClF3N4O5S
Molecular Weight:587.019
Hs Code.:
Mol file:114798-59-3.mol

Synonyms:

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Chemical Property of 1H-Imidazole-5-acetic acid, 2-butyl-4-chloro-1-[[4-[[2-[[(trifluoromethyl)sulfonyl]amino]benzoyl]amino] phenyl]methyl]-, methyl ester

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Technology Process of 1H-Imidazole-5-acetic acid, 2-butyl-4-chloro-1-[[4-[[2-[[(trifluoromethyl)sulfonyl]amino]benzoyl]amino] phenyl]methyl]-, methyl ester

There total 10 articles about 1H-Imidazole-5-acetic acid, 2-butyl-4-chloro-1-[[4-[[2-[[(trifluoromethyl)sulfonyl]amino]benzoyl]amino] phenyl]methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 80798-76-1
N-(trifluoromethanesulfonyl)anthranilic acid chloride

: 114772-05-3
methyl 2-butyl-4-chloro-1-(4-aminobenzyl)-imidazole-5-acetate

: 114798-59-3
methyl 2-n-butyl-4-chloro-1-<<4-<2-(trifluoromethanesulfonamido)benzamido>phenyl>methyl>imidazole-5-acetate

Guidance literature:: In dichloromethane; at 25 ℃; for 2.5h;
DOI:10.1021/jm00167a007

Reference yield:

: 114772-05-3
methyl 2-butyl-4-chloro-1-(4-aminobenzyl)-imidazole-5-acetate

: 114798-59-3
methyl 2-n-butyl-4-chloro-1-<<4-<2-(trifluoromethanesulfonamido)benzamido>phenyl>methyl>imidazole-5-acetate

Guidance literature:: With sodium hydrogencarbonate; In hexane; dichloromethane; ethyl acetate;

Reference yield:

: 114799-92-7
2-Butyl-4-chloro-1-[(4-nitrophenyl)methyl]-1H-imidazole-5-methanol

: 114798-59-3
methyl 2-n-butyl-4-chloro-1-<<4-<2-(trifluoromethanesulfonamido)benzamido>phenyl>methyl>imidazole-5-acetate

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / CHCl₃ / 2 h / 0 - 20 °C

2: dimethylsulfoxide

3: 98 percent / 12 N HCl, glacial acetic acid / 6 h / Heating

4: 71 percent / 3.1 M HCl / dioxane / 7.5 h / Heating

5: 98 percent / iron, glacial acetic acid / methanol / 5.5 h / Heating

6: 61 percent / CH₂Cl₂ / 2.5 h / 25 °C

With hydrogenchloride; thionyl chloride; iron; acetic acid; In 1,4-dioxane; methanol; dichloromethane; chloroform; dimethyl sulfoxide;
DOI:10.1021/jm00167a007