1H-Imidazole-5-acetic acid, 2-butyl-4-chloro-1-[[4-[[3-[[(trifluoromethyl)sulfonyl]amino]benzoyl]amino] phenyl]methyl]-, methyl ester

Base Information

Chemical Name:1H-Imidazole-5-acetic acid, 2-butyl-4-chloro-1-[[4-[[3-[[(trifluoromethyl)sulfonyl]amino]benzoyl]amino] phenyl]methyl]-, methyl ester
CAS No.:114798-62-8
Molecular Formula:C₂₅H₂₆ClF₃N₄O₅S
Molecular Weight:587.019
Hs Code.:
Mol file:114798-62-8.mol

Synonyms:

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Chemical Property of 1H-Imidazole-5-acetic acid, 2-butyl-4-chloro-1-[[4-[[3-[[(trifluoromethyl)sulfonyl]amino]benzoyl]amino] phenyl]methyl]-, methyl ester

Chemical Property:

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Technology Process of 1H-Imidazole-5-acetic acid, 2-butyl-4-chloro-1-[[4-[[3-[[(trifluoromethyl)sulfonyl]amino]benzoyl]amino] phenyl]methyl]-, methyl ester

There total 8 articles about 1H-Imidazole-5-acetic acid, 2-butyl-4-chloro-1-[[4-[[3-[[(trifluoromethyl)sulfonyl]amino]benzoyl]amino] phenyl]methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114799-92-7
2-Butyl-4-chloro-1-[(4-nitrophenyl)methyl]-1H-imidazole-5-methanol

: 114798-62-8
{2-Butyl-5-chloro-3-[4-(3-trifluoromethanesulfonylamino-benzoylamino)-benzyl]-3H-imidazol-4-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / CHCl₃ / 2 h / 0 - 20 °C

2: dimethylsulfoxide

3: 98 percent / 12 N HCl, glacial acetic acid / 6 h / Heating

4: 71 percent / 3.1 M HCl / dioxane / 7.5 h / Heating

5: 98 percent / iron, glacial acetic acid / methanol / 5.5 h / Heating

6: CH₂Cl₂ / 2.5 h / 25 °C

With hydrogenchloride; thionyl chloride; iron; acetic acid; In 1,4-dioxane; methanol; dichloromethane; chloroform; dimethyl sulfoxide;
DOI:10.1021/jm00167a007

Reference yield:

: 125665-56-7
2-Butyl-4-chloro-5-chloromethyl-1-(4-nitro-benzyl)-1H-imidazole

: 114798-62-8
{2-Butyl-5-chloro-3-[4-(3-trifluoromethanesulfonylamino-benzoylamino)-benzyl]-3H-imidazol-4-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylsulfoxide

2: 98 percent / 12 N HCl, glacial acetic acid / 6 h / Heating

3: 71 percent / 3.1 M HCl / dioxane / 7.5 h / Heating

4: 98 percent / iron, glacial acetic acid / methanol / 5.5 h / Heating

5: CH₂Cl₂ / 2.5 h / 25 °C

With hydrogenchloride; iron; acetic acid; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00167a007

Reference yield:

: 114771-99-2
2-Butyl-4-chloro-5-(cyanomethyl]-l-[(4-nitrophenyl)-methyl]imidazole

: 114798-62-8
{2-Butyl-5-chloro-3-[4-(3-trifluoromethanesulfonylamino-benzoylamino)-benzyl]-3H-imidazol-4-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / 12 N HCl, glacial acetic acid / 6 h / Heating

2: 71 percent / 3.1 M HCl / dioxane / 7.5 h / Heating

3: 98 percent / iron, glacial acetic acid / methanol / 5.5 h / Heating

4: CH₂Cl₂ / 2.5 h / 25 °C

With hydrogenchloride; iron; acetic acid; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm00167a007