N-(2-Chlorophenyl)hydrazinecarboxamide

Base Information

• Chemical Name: N-(2-Chlorophenyl)hydrazinecarboxamide
• CAS No.: 35580-76-8
• Molecular Formula: C7H8 Cl N3 O
• Molecular Weight: 185.613
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID50956967
• Nikkaji Number: J1.584.552J
• ChEMBL ID: CHEMBL2296370
• Mol file: 35580-76-8.mol

Synonyms:35580-76-8;N-(2-Chlorophenyl)hydrazinecarboxamide;N-(2-chlorophenyl)-1-hydrazinecarboxamide;1-amino-3-(2-chlorophenyl)urea;4-(2-chlorophenyl)semicarbazide;3-amino-1-(2-chlorophenyl)urea;SCHEMBL9036644;CHEMBL2296370;DTXSID50956967;MFCD03791165;AKOS005069674;SB86283;N-(2-chlorophenyl)hydrazine carboxamide;CS-0096191;FT-0605527;FT-0680096;N-(2-Chlorophenyl)hydrazinecarboximidic acid;W18576;A874586;12T-0883;J-522898

Chemical Property of N-(2-Chlorophenyl)hydrazinecarboxamide

Chemical Property:

• Melting Point: 114-116°C
• Boiling Point: °Cat760mmHg
• PKA: 11.46±0.20(Predicted)
• Flash Point: °C
• PSA: 67.15000
• Density: 1.422g/cm³
• LogP: 2.49940
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 185.0355896
• Heavy Atom Count: 12
• Complexity: 165

Purity/Quality:

97% ^*data from raw suppliers

N-(2-Chlorophenyl)hydrazinecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)NC(=O)NN)Cl

Technology Process of N-(2-Chlorophenyl)hydrazinecarboxamide

There total 6 articles about N-(2-Chlorophenyl)hydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

phenyl N-(2-chlorophenyl)carbamate → N-(2-chlorophenyl)hydrazinecarboxamide (35580-76-8)

Guidance literature:

With hydrazine hydrate; In ethanol; at 75 ℃; for 1h;

Reference yield: 82.0%

(2-chlorophenyl)urea (114-38-5) → N-(2-chlorophenyl)hydrazinecarboxamide (35580-76-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 48h; Reflux;

DOI:10.1007/s00044-012-0271-z

Reference yield: 75.0%

o-chlorophenyl isocyanate (3320-83-0) → N-(2-chlorophenyl)hydrazinecarboxamide (35580-76-8)

Guidance literature:

With hydrazine hydrate; In dichloromethane; at -60 - 20 ℃;

DOI:10.1021/jm021074j

upstream raw materials:

(2-chlorophenyl)urea

o-chlorophenyl isocyanate

sodium isocyanate

o-chloroaniline

Downstream raw materials:

2-N-(2-chlorophenyl)-1,3,4-oxadiazole-2,5-diamine

benzo[1,3]dioxole-5-carbaldehyde 4-(2-chloro-phenyl)-semicarbazone

C₁₅H₁₄ClN₃O₂

2',3',5'-tri-O-acetyl-2-[3-(2-chlorophenyl)aminocarbonyltriazene-1-yl]adenosine