2,4-Pyrimidinediamine, 5-((4-(aminomethyl)-3,5-dimethoxyphenyl)methyl)-

Base Information

Chemical Name:2,4-Pyrimidinediamine, 5-((4-(aminomethyl)-3,5-dimethoxyphenyl)methyl)-
CAS No.:55687-65-5
Molecular Formula:C14H19N5O2
Molecular Weight:289.333
Hs Code.:
DSSTox Substance ID:DTXSID50204213
Wikidata:Q83077664

Synonyms:BRN 0694237;2,4-Pyrimidinediamine, 5-((4-(aminomethyl)-3,5-dimethoxyphenyl)methyl)-;5-((4-(Aminomethyl)-3,5-dimethoxyphenyl)methyl)-2,4-pyrimidinediamine;5-25-13-00399 (Beilstein Handbook Reference);55687-65-5;SCHEMBL11852767;DTXSID50204213;LS-134950

Suppliers and Price of 2,4-Pyrimidinediamine, 5-((4-(aminomethyl)-3,5-dimethoxyphenyl)methyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,4-Pyrimidinediamine, 5-((4-(aminomethyl)-3,5-dimethoxyphenyl)methyl)-

Chemical Property:

Vapor Pressure:1.48E-12mmHg at 25°C
Boiling Point:559.7°Cat760mmHg
Flash Point:292.3°C
Density:1.269g/cm³
XLogP3:0.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:289.15387487
Heavy Atom Count:21
Complexity:306

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1CN)OC)CC2=CN=C(N=C2N)N

Technology Process of 2,4-Pyrimidinediamine, 5-((4-(aminomethyl)-3,5-dimethoxyphenyl)methyl)-

There total 9 articles about 2,4-Pyrimidinediamine, 5-((4-(aminomethyl)-3,5-dimethoxyphenyl)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 55687-58-6
α-(2,4-diamino-5-pyrimidinyl)-2,6-dimethoxy-p-tolunitrile

: 55687-65-5
4-<(2,4-diamino-5-pyrimidinyl)methyl>-2,6-dimethoxy-benzylamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In hydrogenchloride; methanol; for 5h; Ambient temperature;

Reference yield:

: 55687-60-0
methyl 3,5-dimethoxyterephthalamate

: 55687-65-5
4-<(2,4-diamino-5-pyrimidinyl)methyl>-2,6-dimethoxy-benzylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 69 percent / sodium bis(2-methoxyethoxy)aluminum hyride, morpholine / toluene / 4 h / -15 °C

2: 73 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C

3: 59 percent / propan-2-ol / 0.5 h / Heating

4: 73 percent / sodium methylate / ethanol / 40 h / Heating

5: 55 percent / phosphorus oxychloride / pyridine / 3 h / 20 - 30 °C

6: 85 percent / H₂ / Pd-C / aq. HCl; methanol / 5 h / Ambient temperature

With morpholine; hydrogen; sodium methylate; sodium bis(2-methoxyethoxy)aluminium dihydride; trichlorophosphate; palladium on activated charcoal; In pyridine; hydrogenchloride; methanol; ethanol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 74731-68-3
4-Formyl-2,6-dimethoxy-benzamide

: 55687-65-5
4-<(2,4-diamino-5-pyrimidinyl)methyl>-2,6-dimethoxy-benzylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C

2: 59 percent / propan-2-ol / 0.5 h / Heating

3: 73 percent / sodium methylate / ethanol / 40 h / Heating

4: 55 percent / phosphorus oxychloride / pyridine / 3 h / 20 - 30 °C

5: 85 percent / H₂ / Pd-C / aq. HCl; methanol / 5 h / Ambient temperature

With hydrogen; sodium methylate; trichlorophosphate; palladium on activated charcoal; In pyridine; hydrogenchloride; methanol; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;