3-Cyclohexylcarbonyl-4-(2-methylphenylamino)-8-methoxyquinoline

Base Information

Chemical Name:3-Cyclohexylcarbonyl-4-(2-methylphenylamino)-8-methoxyquinoline
CAS No.:115607-62-0
Molecular Formula:C24H26N2O2
Molecular Weight:374.483
Hs Code.:
DSSTox Substance ID:DTXSID801156410
Nikkaji Number:J510.407F
ChEMBL ID:CHEMBL115240
Mol file:115607-62-0.mol

Synonyms:CHEMBL115240;SCHEMBL9652111;SJRBUQNHCZOJAL-UHFFFAOYSA-N;DTXSID801156410;BDBM50001255;3-cyclohexylcarbonyl-4-(2-methylphenylamino)-8-methoxyquinoline;Cyclohexyl-(8-methoxy-4-o-tolylamino-quinolin-3-yl)-methanone;4-[(2-Methylphenyl)amino]-8-methoxy-3-(cyclohexylcarbonyl)quinoline;Cyclohexyl[8-methoxy-4-[(2-methylphenyl)amino]-3-quinolinyl]methanone;115607-62-0

Suppliers and Price of 3-Cyclohexylcarbonyl-4-(2-methylphenylamino)-8-methoxyquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Cyclohexylcarbonyl-4-(2-methylphenylamino)-8-methoxyquinoline

Chemical Property:

XLogP3:6.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:374.199428076
Heavy Atom Count:28
Complexity:519

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=CC=C1NC2=C3C=CC=C(C3=NC=C2C(=O)C4CCCCC4)OC

Technology Process of 3-Cyclohexylcarbonyl-4-(2-methylphenylamino)-8-methoxyquinoline

There total 6 articles about 3-Cyclohexylcarbonyl-4-(2-methylphenylamino)-8-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.4%

: 123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6
1,4-dioxane

: 115607-84-6
4-chloro-3-cyclohexylcarbonyl-8-methoxyquinoline

: 95-53-4
o-toluidine

: 115607-62-0
3-cyclohexylcarbonyl-4-(2-methylphenylamino)-8-methoxyquinoline

Guidance literature:: In dichloromethane;

Reference yield: 8.0%

: 115607-84-6
4-chloro-3-cyclohexylcarbonyl-8-methoxyquinoline

: 95-53-4
o-toluidine

: 115607-62-0
3-cyclohexylcarbonyl-4-(2-methylphenylamino)-8-methoxyquinoline

Guidance literature:: In 1,4-dioxane; for 2h; Heating;
DOI:10.1021/jm00096a018

Reference yield:

: 90-04-0
2-methoxy-phenylamine

: 115607-62-0
3-cyclohexylcarbonyl-4-(2-methylphenylamino)-8-methoxyquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / ethanol / 3 h / Heating

2: 1.) NaH / 1.) THF, 2.) THF, 3 h

3: 35 percent / diphenyl ether / 1.5 h / Heating

4: POCl₃ / CHCl₃ / 2.5 h / Heating

5: 8 percent / dioxane / 2 h / Heating

With sodium hydride; trichlorophosphate; In 1,4-dioxane; diphenylether; ethanol; chloroform;
DOI:10.1021/jm00096a018