2-(2-Chlorophenyl)-5,7-dihydroxychroman-4-one

Base Information

Chemical Name:2-(2-Chlorophenyl)-5,7-dihydroxychroman-4-one
CAS No.:115782-40-6
Molecular Formula:C15H11ClO4
Molecular Weight:290.703
Hs Code.:
DSSTox Substance ID:DTXSID40552098
Nikkaji Number:J2.613.396C
Mol file:115782-40-6.mol

Synonyms:115782-40-6;2-(2-chlorophenyl)-5,7-dihydroxychroman-4-one;2-(2-chlorophenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-4-one;PTP inhibitor, 4d;DTXSID40552098;BDBM243052;2-(2-Chlorophenyl)-5,7-dihydroxy-2,3-dihydro-4H-1-benzopyran-4-one

Suppliers and Price of 2-(2-Chlorophenyl)-5,7-dihydroxychroman-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-(2-Chlorophenyl)-5,7-dihydroxychroman-4-one

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:290.0345865
Heavy Atom Count:20
Complexity:375

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=CC=C3Cl

Technology Process of 2-(2-Chlorophenyl)-5,7-dihydroxychroman-4-one

There total 3 articles about 2-(2-Chlorophenyl)-5,7-dihydroxychroman-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 861107-97-3
(E)-3-(2-chlorophenyl)-1-(2'-hydroxy-4',6'-dimethoxyphenyl)prop-2-en-1-one

: 115782-40-6
2'-chloro-5,7-dihydroxyflavanone

Guidance literature:: With hydrogen iodide; In acetic acid; for 2h; Heating;
DOI:10.1080/00397910801991465

Reference yield:

: 89-98-5
2-chloro-benzaldehyde

: 115782-40-6
2'-chloro-5,7-dihydroxyflavanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide

2: sodium acetate

3: hydrogenchloride / methanol

With hydrogenchloride; sodium acetate; potassium hydroxide; In methanol; 1: |Claisen-Schmidt Condensation;
DOI:10.1016/j.bmcl.2021.128306

Reference yield:

: 480-66-0,67471-34-5
2,4,6-trihydroxyacetophenone

: 115782-40-6
2'-chloro-5,7-dihydroxyflavanone

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 0 - 20 °C

2: potassium hydroxide / ethanol

3: sodium acetate / ethanol / Reflux

4: hydrogenchloride / methanol; water / 0.5 h / Reflux

With hydrogenchloride; sodium acetate; potassium carbonate; potassium hydroxide; In methanol; ethanol; water; acetone; 2: Claisen Schmidt condensation;