3-chloro-N-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

Base Information

Chemical Name:3-chloro-N-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS No.:7169-24-6
Molecular Formula:C₁₀H₁₀N₂O₃
Molecular Weight:206.201
Hs Code.:
DSSTox Substance ID:DTXSID30412617

Synonyms:ZINC02793831;7169-24-6;3-CHLORO-N-(4-ISOPROPYLPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXAMIDE;DTXSID30412617;3-chloro-N-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide;AKOS003751846

Suppliers and Price of 3-chloro-N-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 3-chloro-N-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.34g/cm³
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:314.0934388
Heavy Atom Count:22
Complexity:398

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C1=CC=C(C=C1)NC(=O)C2=NN3C=CC=NC3=C2Cl

Technology Process of 3-chloro-N-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

There total 2 articles about 3-chloro-N-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1521-38-6
2,3-dimethoxybenzoic acid

: 7169-24-6
2,3-Dimethoxy-ω-diazo-acetophenon

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2

With oxalyl dichloride;
DOI:10.1055/s-2002-20478

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 7169-06-4
2,3-dimethoxybenzoyl chloride

: 7169-24-6
2,3-Dimethoxy-ω-diazo-acetophenon

Guidance literature:: In diethyl ether;

Reference yield:

: 7169-24-6
2,3-Dimethoxy-ω-diazo-acetophenon

: 3-(4-chloro-phenyl)-7-methoxy-benzofuran

Guidance literature:: Multi-step reaction with 3 steps

1: NaOAc / acetic acid / 20 °C

2: (i-Pr)2NEt / CH₂Cl₂

3: Na₂CO₃ / Pd(PPh₃)4 / dimethylformamide / 3 h / 90 °C

With sodium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; acetic acid; N,N-dimethyl-formamide; 3: Suzuki reaction;
DOI:10.1055/s-2002-20478