Technology Process of Nonanoic acid, 8-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-6-methyl-, ethyl
ester
There total 5 articles about Nonanoic acid, 8-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-6-methyl-, ethyl
ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 77 percent / imidazole / dimethylformamide / 18 h / Ambient temperature
2: 1.) O3, 2.) Zn AcOH / 1a.) CH2Cl2, -78 deg C, 1b.) RT, 0.5 h, 2.) RT, 0.5 h
3: 1.) NaH / 1.) THF, <20 deg C, 10 min, 2.) RT, 4 h
4: 98 percent / H2 / Pd/C / ethyl acetate / 3 h / 2068.6 Torr / Ambient temperature
With
1H-imidazole; hydrogen; sodium hydride; ozone; acetic acid; zinc;
palladium on activated charcoal;
In
ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00254a042
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 84 percent / diethyl ether / 0.17 h / 0 °C
2: 77 percent / imidazole / dimethylformamide / 18 h / Ambient temperature
3: 1.) O3, 2.) Zn AcOH / 1a.) CH2Cl2, -78 deg C, 1b.) RT, 0.5 h, 2.) RT, 0.5 h
4: 1.) NaH / 1.) THF, <20 deg C, 10 min, 2.) RT, 4 h
5: 98 percent / H2 / Pd/C / ethyl acetate / 3 h / 2068.6 Torr / Ambient temperature
With
1H-imidazole; hydrogen; sodium hydride; ozone; acetic acid; zinc;
palladium on activated charcoal;
In
diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00254a042
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 59 percent / pyridinium dichromate / CH2Cl2 / 19 h / Ambient temperature
2: 84 percent / diethyl ether / 0.17 h / 0 °C
3: 77 percent / imidazole / dimethylformamide / 18 h / Ambient temperature
4: 1.) O3, 2.) Zn AcOH / 1a.) CH2Cl2, -78 deg C, 1b.) RT, 0.5 h, 2.) RT, 0.5 h
5: 1.) NaH / 1.) THF, <20 deg C, 10 min, 2.) RT, 4 h
6: 98 percent / H2 / Pd/C / ethyl acetate / 3 h / 2068.6 Torr / Ambient temperature
With
1H-imidazole; dipyridinium dichromate; hydrogen; sodium hydride; ozone; acetic acid; zinc;
palladium on activated charcoal;
In
diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00254a042
