14-Hydroxymorphine

Base Information

Chemical Name:14-Hydroxymorphine
CAS No.:3371-56-0
Molecular Formula:C17H19NO4
Molecular Weight:301.342
Hs Code.:
UNII:87AZ2QM6Z7
DSSTox Substance ID:DTXSID20955326
Nikkaji Number:J188.359C
Wikidata:Q76309827
ChEMBL ID:CHEMBL1951703
Mol file:3371-56-0.mol

Synonyms:14-Hydroxymorphine;Morphine, 14-hydroxy-;RAM-371;3371-56-0;87AZ2QM6Z7;Morphinan-3,6-alpha,14-triol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-;UNII-87AZ2QM6Z7;SCHEMBL1346096;CHEMBL1951703;DTXSID20955326;Morphinan-2,6.alpha.,14-triol, 7,8-didehydro-4,5.alpha.-epoxy-17-methyl-;Morphinan-3,6,14-triol, 7,8-didehydro-4,5-epoxy-17-methyl-, (5.alpha.,6.alpha.)-;LS-92175;17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6,14-triol

Suppliers and Price of 14-Hydroxymorphine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 14-Hydroxymorphine

Chemical Property:

Vapor Pressure:8.36E-12mmHg at 25°C
Boiling Point:523.9°Cat760mmHg
Flash Point:270.6°C
PSA：73.16000
Density:1.54g/cm³
LogP:0.25090
XLogP3:0.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:301.13140809
Heavy Atom Count:22
Complexity:539

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC23C4C(C=CC2(C1CC5=C3C(=C(C=C5)O)O4)O)O
Isomeric SMILES:CN1CC[C@]23[C@@H]4[C@H](C=C[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O)O

Technology Process of 14-Hydroxymorphine

There total 6 articles about 14-Hydroxymorphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 41135-98-2
14-hydroxymorphinone

: 3371-56-0
6α-oxymorphol

Guidance literature:: With L-Selectride; In tetrahydrofuran; at 97 ℃;
DOI:10.1021/ol051010d

Reference yield: 94.0%

: 57-27-2
MORPHIN

: 41135-98-2
14-hydroxymorphinone

: 3371-56-0
6α-oxymorphol

Guidance literature:: With D-glucose; In methanol; at 29 - 30 ℃; for 120h; Bacillus spec.;

Reference yield:

: 508-54-3
14-hydroxycodeinone

: 3371-56-0
6α-oxymorphol

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / BBr₃ / CH₂Cl₂ / 24 h / 20 °C

2: 97 percent / Li-Selectride / tetrahydrofuran / 97 °C

With boron tribromide; L-Selectride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol051010d