3-Pyridinecarboxylic acid, 6-methyl-4-[(2,3,5-trimethoxyphenyl)methyl]-

Base Information

Chemical Name:3-Pyridinecarboxylic acid, 6-methyl-4-[(2,3,5-trimethoxyphenyl)methyl]-
CAS No.:116115-00-5
Molecular Formula:C17H19NO5
Molecular Weight:317.342
Hs Code.:
Mol file:116115-00-5.mol

Synonyms:

Suppliers and Price of 3-Pyridinecarboxylic acid, 6-methyl-4-[(2,3,5-trimethoxyphenyl)methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of 3-Pyridinecarboxylic acid, 6-methyl-4-[(2,3,5-trimethoxyphenyl)methyl]-

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylic acid, 6-methyl-4-[(2,3,5-trimethoxyphenyl)methyl]-

There total 9 articles about 3-Pyridinecarboxylic acid, 6-methyl-4-[(2,3,5-trimethoxyphenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 116114-99-9
6-Methyl-1-(2,3,5-trimethoxy-phenyl)-1H-furo[3,4-c]pyridin-3-one

: 116115-00-5
6-Methyl-4-(2,3,5-trimethoxy-benzyl)-nicotinic acid

Guidance literature:: With potassium hydroxide; zinc copper; In pyridine; for 72h; Heating;
DOI:10.1016/S0040-4020(01)87704-8

Reference yield:

: 77924-01-7
N,N-diisopropylnicotinamide

: 116115-00-5
6-Methyl-4-(2,3,5-trimethoxy-benzyl)-nicotinic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-BuLi, 2,2,6,6-tetramethylpiperidine / 1.) hexane/DME, -78 deg C, 1 h; 2.) DME, 15 min

2: 58 percent / 1,2-dimethoxy-ethane / 1.) 30 min, -78 deg C; 2.) 8 h, room temp.

3: 56 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 4 h / Ambient temperature

4: 60 percent / benzenesulfonyl chloride / acetonitrile / 4 h

5: NaBH₄ / ethanol / 12 h / Ambient temperature

6: formic acid / 7 h / Heating

7: 63 percent / zinc-copper couple, 10 percent aq. KOH / pyridine / 72 h / Heating

With 2,2,6,6-tetramethyl-piperidine; potassium hydroxide; sodium tetrahydroborate; n-butyllithium; formic acid; zinc copper; benzenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; In pyridine; 1,2-dimethoxyethane; ethanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(01)87704-8

Reference yield:

: 116114-87-5
3,5-dimethoxy-N-N-dimethylbenzamide

: 116115-00-5
6-Methyl-4-(2,3,5-trimethoxy-benzyl)-nicotinic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 89 percent / NBS / CCl₄ / 2 h / Heating

2: 77 percent / K₂CO₃ / 4 h / Heating

3: 58 percent / 1,2-dimethoxy-ethane / 1.) 30 min, -78 deg C; 2.) 8 h, room temp.

4: 56 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 4 h / Ambient temperature

5: 60 percent / benzenesulfonyl chloride / acetonitrile / 4 h

6: NaBH₄ / ethanol / 12 h / Ambient temperature

7: formic acid / 7 h / Heating

8: 63 percent / zinc-copper couple, 10 percent aq. KOH / pyridine / 72 h / Heating

With potassium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; formic acid; zinc copper; potassium carbonate; benzenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; In pyridine; tetrachloromethane; 1,2-dimethoxyethane; ethanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(01)87704-8