L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-isoleucyl-N-[5-[[(phenylmethoxy)carb onyl]amino]-1-[[4-(phenylmethyl)-1-piperidinyl]carbonyl]pentyl]-, (S)-

Base Information

Chemical Name:L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-isoleucyl-N-[5-[[(phenylmethoxy)carb onyl]amino]-1-[[4-(phenylmethyl)-1-piperidinyl]carbonyl]pentyl]-, (S)-
CAS No.:116194-19-5
Molecular Formula:C₄₆H₆₃N₅O₇
Molecular Weight:798.036
Hs Code.:
Mol file:116194-19-5.mol

L-Phenylalaninamide,
N-[(1,1-dimethylethoxy)carbonyl]-L-isoleucyl-N-[5-[[(phenylmethoxy)carb
onyl]amino]-1-[[4-(phenylmethyl)-1-piperidinyl]carbonyl]pentyl]-, (S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-isoleucyl-N-[5-[[(phenylmethoxy)carb onyl]amino]-1-[[4-(phenylmethyl)-1-piperidinyl]carbonyl]pentyl]-, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

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Useful:

Technology Process of L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-isoleucyl-N-[5-[[(phenylmethoxy)carb onyl]amino]-1-[[4-(phenylmethyl)-1-piperidinyl]carbonyl]pentyl]-, (S)-

There total 12 articles about L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-isoleucyl-N-[5-[[(phenylmethoxy)carb onyl]amino]-1-[[4-(phenylmethyl)-1-piperidinyl]carbonyl]pentyl]-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 13139-16-7
N-(t-butoxycarbonyl)-isoleucine

: 116227-14-6
[(S)-5-((S)-2-Amino-3-phenyl-propionylamino)-6-(4-benzyl-piperidin-1-yl)-6-oxo-hexyl]-carbamic acid benzyl ester; hydrochloride

: 116194-19-5,116261-94-0
{(S)-6-(4-Benzyl-piperidin-1-yl)-5-[(S)-2-(2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionylamino]-6-oxo-hexyl}-carbamic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1.) -15 deg C, 1 h; 2.) 4 deg C, 18 h;
DOI:10.1248/cpb.36.1289

Reference yield: 50.0%

: 13139-16-7,35264-07-4,55721-65-8,55780-90-0,116194-21-9
N-tert-butyloxy-isoleucine

: 116227-14-6
[(S)-5-((S)-2-Amino-3-phenyl-propionylamino)-6-(4-benzyl-piperidin-1-yl)-6-oxo-hexyl]-carbamic acid benzyl ester; hydrochloride

: 116194-19-5,116261-94-0
{(S)-6-(4-Benzyl-piperidin-1-yl)-5-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionylamino]-6-oxo-hexyl}-carbamic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1.) -15 deg C, 1 h; 2.) 4 deg C, 18 h;
DOI:10.1248/cpb.36.1289

Reference yield:

: 31252-42-3
4-benzylpyperidine

: 116194-19-5,116261-94-0
{(S)-6-(4-Benzyl-piperidin-1-yl)-5-[(S)-2-(2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionylamino]-6-oxo-hexyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / ethyl chloroformate, Et₃N / tetrahydrofuran / 18 h / 4 °C

2: HCl / dioxane

3: 36 percent / HOBt, Et₃N, DCC / dimethylformamide / 1.) -15 deg C, 1 h; 2.) 4 deg C, 18 h

4: HCl / dioxane

5: 57 percent / HOBt, Et₃N, DCC / dimethylformamide / 1.) -15 deg C, 1 h; 2.) 4 deg C, 18 h

With hydrogenchloride; chloroformic acid ethyl ester; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.1289