8-Chloro-10-[3-(dimethylamino)propyl]-2-methoxy-10h-phenothiazin-1-ol

Base Information

Chemical Name:8-Chloro-10-[3-(dimethylamino)propyl]-2-methoxy-10h-phenothiazin-1-ol
CAS No.:21658-48-0
Molecular Formula:C18H21ClN2O2S
Molecular Weight:364.8895
Hs Code.:
DSSTox Substance ID:DTXSID70944260
Mol file:21658-48-0.mol

Synonyms:21658-48-0;BRN 1162953;8-chloro-10-[3-(dimethylamino)propyl]-2-methoxy-10h-phenothiazin-1-ol;8-Hydroxy-7-methoxychlorpromazine;DTXSID70944260;Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-8-hydroxy-7-methoxy-

Suppliers and Price of 8-Chloro-10-[3-(dimethylamino)propyl]-2-methoxy-10h-phenothiazin-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 8-Chloro-10-[3-(dimethylamino)propyl]-2-methoxy-10h-phenothiazin-1-ol

Chemical Property:

Vapor Pressure:1.85E-11mmHg at 25°C
Boiling Point:520.7°Cat760mmHg
Flash Point:268.7°C
PSA：61.24000
Density:1.278g/cm³
LogP:4.67360
XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:364.1012268
Heavy Atom Count:24
Complexity:415

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)CCCN1C2=C(C=CC(=C2)Cl)SC3=C1C(=C(C=C3)OC)O

Technology Process of 8-Chloro-10-[3-(dimethylamino)propyl]-2-methoxy-10h-phenothiazin-1-ol

There total 6 articles about 8-Chloro-10-[3-(dimethylamino)propyl]-2-methoxy-10h-phenothiazin-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36798-13-7
[3-(2-benzyloxy-8-chloro-3-methoxy-phenothiazin-10-yl)-propyl]-dimethyl-amine

: 21658-48-0
8-Hydroxy-7-methoxy-chlorpromazin

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; under 2585.7 Torr;

Reference yield:

: 36798-12-6
2-benzyloxy-8-chloro-3-methoxy-10H-phenothiazine

: 21658-48-0
8-Hydroxy-7-methoxy-chlorpromazin

Guidance literature:: Multi-step reaction with 2 steps

1: (i) NaH, DMSO, (ii) /BRN= 605294/

2: H₂ / Pd-C / methanol / 2585.7 Torr

With hydrogen; palladium on activated charcoal; In methanol;

Reference yield:

: 63057-72-7
2-benzyloxy-5-bromoanisole

: 21658-48-0
8-Hydroxy-7-methoxy-chlorpromazin

Guidance literature:: Multi-step reaction with 6 steps

1: aq. HNO₃ / acetic acid

2: NaOH / aq. ethanol

3: H₂ / Pt

4: K₂CO₃ / Cu / dimethylformamide / 24 h / Heating

5: (i) NaH, DMSO, (ii) /BRN= 605294/

6: H₂ / Pd-C / methanol / 2585.7 Torr

With sodium hydroxide; hydrogen; nitric acid; potassium carbonate; palladium on activated charcoal; copper; platinum; In methanol; ethanol; acetic acid; N,N-dimethyl-formamide;