1-[2-(Dimethylamino)phenyl]cyclohexanol

Base Information

• Chemical Name: 1-[2-(Dimethylamino)phenyl]cyclohexanol
• CAS No.: 13288-48-7
• Molecular Formula: C14H21NO
• Molecular Weight: 219.327
• NSC Number: 127387
• DSSTox Substance ID: DTXSID10298991
• Nikkaji Number: J2.697.293K
• Wikidata: Q82041138

Synonyms:13288-48-7;1-[2-(dimethylamino)phenyl]cyclohexanol;NSC127387;DTXSID10298991;NSC-127387

Chemical Property of 1-[2-(Dimethylamino)phenyl]cyclohexanol

Chemical Property:

• Vapor Pressure: 1.69E-05mmHg at 25°C
• Boiling Point: 350°Cat760mmHg
• Flash Point: 165°C
• Density: 1.074g/cm³
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 219.162314293
• Heavy Atom Count: 16
• Complexity: 221

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC=CC=C1C2(CCCCC2)O

Technology Process of 1-[2-(Dimethylamino)phenyl]cyclohexanol

There total 2 articles about 1-[2-(Dimethylamino)phenyl]cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + N,N-dimethyl-aniline (121-69-7,77733-26-7) → 1-(o-Dimethylaminophenyl)-cyclohexanol (13288-48-7)

Guidance literature:

N,N-dimethyl-aniline; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; hexane; at -78 - 20 ℃; for 2h; Inert atmosphere; Schlenk technique;

cyclohexanone; In diethyl ether; hexane; at 0 ℃; for 2h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.jorganchem.2015.06.011

Reference yield:

→ 1-(o-Dimethylaminophenyl)-cyclohexanol (13288-48-7)

Guidance literature:

Cyclohexanon, Dimethylanilin, Butyl-Li;

Reference yield:

1-(o-Dimethylaminophenyl)-cyclohexanol (13288-48-7) → 2-cyclohex-1-enyl-N,N-dimethyl-aniline (10483-02-0)

Guidance literature:

With sulfuric acid;

DOI:10.1021/jo01345a001

upstream raw materials:

cyclohexanone

N,N-dimethyl-aniline

Downstream raw materials:

2-cyclohex-1-enyl-N,N-dimethyl-aniline

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