DL-2-Hydroxy-5-nitro-Phenylalanine

Base Information

• Chemical Name: DL-2-Hydroxy-5-nitro-Phenylalanine
• CAS No.: 116366-25-7
• Molecular Formula: C9H10N2O5
• Molecular Weight: 226.18600
• Mol file: 116366-25-7.mol

Synonyms:2-Hydroxy-5-nitro-phenylalanin;2-amino-3-(2-hydroxy-5-nitrophenyl)propanoic acid;

Chemical Property of DL-2-Hydroxy-5-nitro-Phenylalanine

Chemical Property:

• PSA: 129.37000
• LogP: 1.47830

Purity/Quality:

99% ^*data from raw suppliers

DL-2-HYDROXY-5-NITRO-PHENYLALANINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-2-Hydroxy-5-nitro-Phenylalanine

There total 4 articles about DL-2-Hydroxy-5-nitro-Phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-tert-Butoxycarbonylamino-3-(2-hydroxy-5-nitro-phenyl)-propionic acid → 2-hydroxy-5-nitro-phenylalanine (116366-25-7,1241677-95-1,62080-85-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1021/jm950028z

Reference yield:

2-hydroxy-phenylalanine (709-16-0,2370-61-8,7423-92-9,24008-77-3) → 2-hydroxy-5-nitro-phenylalanine (116366-25-7,1241677-95-1,62080-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NO₂BF₄, 2.) Et₃N / 1.) MeCN, -18 deg C, 2.) dioxane, H₂O, RT, 16 h

2: 80 percent / CF₃COOH / CH₂Cl₂ / 3 h / Ambient temperature

With nitronium tetrafluoborate; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm950028z

Reference yield:

acetylamino-(2-hydroxy-5-nitro-benzyl)-malonic acid diethyl ester (15959-69-0) → 2-hydroxy-5-nitro-phenylalanine (116366-25-7,1241677-95-1,62080-85-7)

Guidance literature:

With hydrogen bromide;

DOI:10.1021/ja01145a022

upstream raw materials:

acetylamino-(2-hydroxy-5-nitro-benzyl)-malonic acid diethyl ester

2-hydroxy-phenylalanine

2-hydroxy-5-nitrobenzyl chloride