3'-Cytidylic acid, N-benzoyl-2'-deoxy-, mono(2-chlorophenyl) ester, 5'-benzoate, compd. with N,N-diethylethanamine (1:1)

Base Information

• Chemical Name: 3'-Cytidylic acid, N-benzoyl-2'-deoxy-, mono(2-chlorophenyl) ester, 5'-benzoate, compd. with N,N-diethylethanamine (1:1)
• CAS No.: 116454-14-9
• Molecular Formula: C₆H₁₅N*C₂₉H₂₅ClN₃O₉P
• Molecular Weight: 727.151
• Mol file: 116454-14-9.mol

Synonyms:

Chemical Property of 3'-Cytidylic acid, N-benzoyl-2'-deoxy-, mono(2-chlorophenyl) ester, 5'-benzoate, compd. with N,N-diethylethanamine (1:1)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-Cytidylic acid, N-benzoyl-2'-deoxy-, mono(2-chlorophenyl) ester, 5'-benzoate, compd. with N,N-diethylethanamine (1:1)

There total 2 articles about 3'-Cytidylic acid, N-benzoyl-2'-deoxy-, mono(2-chlorophenyl) ester, 5'-benzoate, compd. with N,N-diethylethanamine (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N4-benzoyl-2'-deoxycytidine (4836-13-9) → Benzoic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine (116454-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / BOPDC / pyridine / 5 h / Ambient temperature

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In pyridine;

DOI:10.1016/S0040-4020(01)85111-5

Reference yield:

(5'-O,4-N)-dibenzoyl-2'-deoxycytidine (4803-92-3) + triethylamine (121-44-8) + 4-chlorophenylphosphorodichloridate (772-79-2) → Benzoic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine (116454-14-9)

Guidance literature:

DOI:10.1016/S0040-4020(01)85111-5

Reference yield: 89.5%

N-isobutyryl-2'-deoxyguanosine (68892-42-2) + Benzoic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine (116454-14-9) + 4-chlorophenylphosphorodichloridate (772-79-2) → C49H46Cl2N8O16P2*C6H15N (116454-16-1)

Guidance literature:

With MSNT;

DOI:10.1016/S0040-4020(01)85111-5

upstream raw materials:

(5'-O,4-N)-dibenzoyl-2'-deoxycytidine

triethylamine

4-chlorophenylphosphorodichloridate

N₄-benzoyl-2'-deoxycytidine

Downstream raw materials:

C₄₉H₄₆Cl₂N₈O₁₆P₂*C₆H₁₅N