2-Amino-6-bromonaphthalene

Base Information

• Chemical Name: 2-Amino-6-bromonaphthalene
• CAS No.: 7499-66-3
• Molecular Formula: C10H8BrN
• Molecular Weight: 222.084
• Hs Code.: 2921450090
• Mol file: 7499-66-3.mol

Synonyms:2-Naphthylamine,6-bromo- (6CI,8CI);2-Amino-6-bromonaphthalene;6-Bromo-2-naphthylamine;6-Bromonaphthalen-2-amine;NSC 407685;

Chemical Property of 2-Amino-6-bromonaphthalene

Chemical Property:

• Vapor Pressure: 1.69E-05mmHg at 25°C
• Melting Point: 128 °C
• Refractive Index: 1.718
• Boiling Point: 364.4 °C at 760 mmHg
• PKA: 3.66±0.10(Predicted)
• Flash Point: 174.2 °C
• PSA: 26.02000
• Density: 1.563 g/cm³
• LogP: 3.76570
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99%+ ^*data from raw suppliers

6-Bromo-2-naphthylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Bromonaphthalen-2-amine is used in the new synthesis of alkylsulphanylnaphthalenes and the synthesis and mesomorphic properties of novel naphthylisothiocyanates.

Technology Process of 2-Amino-6-bromonaphthalene

There total 25 articles about 2-Amino-6-bromonaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-bromo-2-naphthoic acid (5773-80-8) → 6-Bromonaphthalen-2-amine (7499-66-3)

Guidance literature:

6-bromo-2-naphthoic acid; With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

With water; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

Reference yield: 94.0%

6-bromo-naphthalen-2-ol (15231-91-1) → 6-Bromonaphthalen-2-amine (7499-66-3)

Guidance literature:

With ammonium bisulfite; ammonia; water; at 150 ℃; for 48h;

Reference yield: 90.0%

6-bromo-2-naphthylhydrazine → 6-Bromonaphthalen-2-amine (7499-66-3)

Guidance literature:

With titanium(III) chloride; water; In N,N-dimethyl-formamide; Reflux; Inert atmosphere;

DOI:10.1039/c1ob05328k

upstream raw materials:

6-bromo-naphthalen-2-ol

2-bromo-6-nitronaphthalene

N-(6-bromo-[2]naphthyl)-acetamide

1,6-dibromonaphthalen-2-amine

Downstream raw materials:

N-(6-bromonaphthalen-2-yl)-methanesulfonamide

benzyl 6-bromonaphthalen-2-ylcarbamate

C₄₀H₄₃N₅O₁₅S₄

tert-butyl [6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-naphthalen-2-yl]carbamate

Refernces

• 1、 -. "Organic electroluminescent compounds and organic electroluminescent device using the same". Paragraph 0408-0413. . Retrieved 2020/12/15.
• 2、 Barnes, David M.,Shekhar, Shashank,Dunn, Travis B.,Barkalow, Jufang H.,Chan, Vincent S.,Franczyk, Thaddeus S.,Haight, Anthony R.,Hengeveld, John E.,Kolaczkowski, Lawrence,Kotecki, Brian J.,Liang, Guangxin,Marek, James C.,McLaughlin, Maureen A.,Montavon, Donna K.,Napier, James J.. "Discovery and Development of Metal-Catalyzed Coupling Reactions in the Synthesis of Dasabuvir, an HCV-Polymerase Inhibitor". . p. 4873 - 4892. Retrieved 2019/02/05.