[1S-[1R,2S(2S,3R)]]-[3-[[3-[[(1,1-Dimethylethoxy)-carbonyl]amino]- 2-hydroxy-4-[4-[[(4-morpholinylcarbonyl)oxy]methyl]phenyl]butyl]amino] -2-hydroxy-1-(phenylmethyl)propyl]carbamic Acid, 1,1-Dimethylethyl est er

Base Information

Chemical Name:[1S-[1R*,2S*(2S*,3R*)]]-[3-[[3-[[(1,1-Dimethylethoxy)-carbonyl]amino]- 2-hydroxy-4-[4-[[(4-morpholinylcarbonyl)oxy]methyl]phenyl]butyl]amino] -2-hydroxy-1-(phenylmethyl)propyl]carbamic Acid, 1,1-Dimethylethyl est er
CAS No.:175233-61-1
Molecular Formula:C₃₆H₅₄N₄O₉
Molecular Weight:686.846
Hs Code.:
Mol file:175233-61-1.mol

[1S-[1R*,2S*(2S*,3R*)]]-[3-[[3-[[(1,1-Dimethylethoxy)-carbonyl]amino]- 2-hydroxy-4-[4-[[(4-morpholinylcarbonyl)oxy]methyl]phenyl]butyl]amino] -2-hydroxy-1-(phenylmethyl)propyl]carbamic Acid, 1,1-Dimethylethyl est er

Synonyms:4-Morpholinecarboxylicacid,[4-[2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-[[3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl]amino]-3-hydroxybutyl]phenyl]methylester, [2R-[1(2S*,3R*),2R*,3S*]]-

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Chemical Property of [1S-[1R*,2S*(2S*,3R*)]]-[3-[[3-[[(1,1-Dimethylethoxy)-carbonyl]amino]- 2-hydroxy-4-[4-[[(4-morpholinylcarbonyl)oxy]methyl]phenyl]butyl]amino] -2-hydroxy-1-(phenylmethyl)propyl]carbamic Acid, 1,1-Dimethylethyl est er

Chemical Property:

Vapor Pressure:3.62E-29mmHg at 25°C
Boiling Point:829.6°Cat760mmHg
Flash Point:455.5°C
PSA：174.90000
Density:1.195g/cm³
LogP:4.27620

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of [1S-[1R*,2S*(2S*,3R*)]]-[3-[[3-[[(1,1-Dimethylethoxy)-carbonyl]amino]- 2-hydroxy-4-[4-[[(4-morpholinylcarbonyl)oxy]methyl]phenyl]butyl]amino] -2-hydroxy-1-(phenylmethyl)propyl]carbamic Acid, 1,1-Dimethylethyl est er

There total 14 articles about [1S-[1R*,2S*(2S*,3R*)]]-[3-[[3-[[(1,1-Dimethylethoxy)-carbonyl]amino]- 2-hydroxy-4-[4-[[(4-morpholinylcarbonyl)oxy]methyl]phenyl]butyl]amino] -2-hydroxy-1-(phenylmethyl)propyl]carbamic Acid, 1,1-Dimethylethyl est er which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 246047-29-0
((S)-3-Amino-1-benzyl-2-hydroxy-propyl)-carbamic acid tert-butyl ester

: Morpholine-4-carboxylic acid 4-((S)-2-tert-butoxycarbonylamino-2-oxiranyl-ethyl)-benzyl ester

: 175233-61-1
Morpholine-4-carboxylic acid 4-[(S)-2-tert-butoxycarbonylamino-4-((S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-3-hydroxy-butyl]-benzyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 4.5h;
DOI:10.1021/jm950717a

Reference yield:

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 175233-61-1
Morpholine-4-carboxylic acid 4-[(S)-2-tert-butoxycarbonylamino-4-((S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-3-hydroxy-butyl]-benzyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 4-methylmorpholine / tetrahydrofuran

2: tetrahydrofuran; diethyl ether / 0 °C

3: HCl / dioxane / 0 °C

4: NaBH₄

5: KOH / ethanol

6: 99 percent / H₂, Pd(OH)2/C / ethanol; ethyl acetate / 4.5 h

7: 84 percent / Et₃N / CH₂Cl₂ / 1.67 h / 0 - 20 °C

8: 1.) LiCl, Ph₃As, 1-methyl-2-pyrrolidinone, tris(dibenzylideneacetone)dipalladium / 1.) 5 min, 2.) a) RT, 2 h, b) 45 deg C, 20 h

9: 1.) O₃, 2.) NaBH₄ / 1.) MeOH, -78 deg C, 2.) MeOH, a) -78 deg C, 10 min, b) 0 deg C, 30 min

10: Et₃N / acetonitrile / 2 h

11: Et₃N / CH₂Cl₂ / 1 h

12: 64 percent / dimethylformamide / 4.5 h / 100 °C

With 4-methyl-morpholine; 1-methyl-pyrrolidin-2-one; hydrogenchloride; palladium dihydroxide; potassium hydroxide; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenyl-arsane; hydrogen; ozone; triethylamine; lithium chloride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950717a

Reference yield:

: 1026977-99-0
C₂₆H₃₃NO₇

: 175233-61-1
Morpholine-4-carboxylic acid 4-[(S)-2-tert-butoxycarbonylamino-4-((S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-3-hydroxy-butyl]-benzyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: tetrahydrofuran; diethyl ether / 0 °C

2: HCl / dioxane / 0 °C

3: NaBH₄

4: KOH / ethanol

5: 99 percent / H₂, Pd(OH)2/C / ethanol; ethyl acetate / 4.5 h

6: 84 percent / Et₃N / CH₂Cl₂ / 1.67 h / 0 - 20 °C

7: 1.) LiCl, Ph₃As, 1-methyl-2-pyrrolidinone, tris(dibenzylideneacetone)dipalladium / 1.) 5 min, 2.) a) RT, 2 h, b) 45 deg C, 20 h

8: 1.) O₃, 2.) NaBH₄ / 1.) MeOH, -78 deg C, 2.) MeOH, a) -78 deg C, 10 min, b) 0 deg C, 30 min

9: Et₃N / acetonitrile / 2 h

10: Et₃N / CH₂Cl₂ / 1 h

11: 64 percent / dimethylformamide / 4.5 h / 100 °C

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; palladium dihydroxide; potassium hydroxide; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenyl-arsane; hydrogen; ozone; triethylamine; lithium chloride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950717a