1,3-Butanediol, 2-methyl-, (2S,3S)-

Base Information

• Chemical Name: 1,3-Butanediol, 2-methyl-, (2S,3S)-
• CAS No.: 116782-41-3
• Molecular Formula: C5H12O2
• Molecular Weight: 104.149
• Mol file: 116782-41-3.mol

Synonyms:1,2-dihydroxy-2-methylbutane;(2S,3S)-2-Methyl-butane-1,3-diol;(2S,3S)-2-methylbutane-1,3-diol;

Chemical Property of 1,3-Butanediol, 2-methyl-, (2S,3S)-

Chemical Property:

• Boiling Point: 200.0±0.0 °C(Predicted)
• PSA: 40.46000
• Density: 0.974±0.06 g/cm3(Predicted)
• LogP: -0.00440

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 1,3-Butanediol, 2-methyl-, (2S,3S)-

There total 2 articles about 1,3-Butanediol, 2-methyl-, (2S,3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-<(2R,3S)-3-hydroxy-2-methylbutanoyl>bornane-10,2-sultam (125664-99-5) → (2S,3S)-2-methylbutane-1,3-diol (116782-41-3) + (2R)-bornane-10,2-sultam (94594-90-8,124224-04-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 3h;

DOI:10.1021/ja00163a045

Reference yield: 79.0%

diethyl (2S,3R)-3-methyl-O-(p-toluenesulfonyloxy)malate (709027-84-9) → (2S,3S)-2-methylbutane-1,3-diol (116782-41-3) + (R)-2-methylbutane-1,4-diol (2938-98-9,70423-38-0,101978-85-2,22644-28-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 55 ℃; for 4h;

DOI:10.1021/jo0497961

Reference yield: 70.0%

(2S,3S)-2-methylbutane-1,3-diol (116782-41-3) + p-toluenesulfonyl chloride (98-59-9) → (2S,3S)-2-methyl-1-(p-toluenesulfonyloxy)-3-butanol (848644-70-2)

Guidance literature:

With triethylamine; In dichloromethane; at -20 - 20 ℃; for 39h;

DOI:10.1021/jo0497961

upstream raw materials:

N-<(2R,3S)-3-hydroxy-2-methylbutanoyl>bornane-10,2-sultam

diethyl (2S,3R)-3-methyl-O-(p-toluenesulfonyloxy)malate

Downstream raw materials:

(2S,3S)-2-methyl-1-(p-toluenesulfonyloxy)-3-butanol

ethyl 2-((2S,4R,5R,6S)-5,6-dimethyl-2-phenyl-1,3-dioxan-4-yl)acetate

(2R,3S)-2-Methyl-3-[4-(4,4,5,5,6,6,7,7,7-nonafluoro-heptyloxy)-benzyloxy]-butyraldehyde

(2R,4S,5S)-4,5-Dimethyl-2-[4-(4,4,5,5,6,6,7,7,7-nonafluoro-heptyloxy)-phenyl]-[1,3]dioxane

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