1-[2-(2-Methoxy-phenoxy)-ethyl]-piperazine

Base Information

• Chemical Name: 1-[2-(2-Methoxy-phenoxy)-ethyl]-piperazine
• CAS No.: 117132-45-3
• Molecular Formula: C13H20N2O2
• Molecular Weight: 236.314
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID50389630
• Nikkaji Number: J632.261A
• Wikidata: Q82185601
• Mol file: 117132-45-3.mol

Synonyms:1-[2-(2-Methoxy-phenoxy)-ethyl]-piperazine;117132-45-3;1-[2-(2-methoxyphenoxy)ethyl]piperazine;1-(2-(2-Methoxyphenoxy)ethyl)piperazine;Oprea1_098154;SCHEMBL3436048;DTXSID50389630;BBL028554;MFCD00438753;STK933724;AKOS000301478;VS-08837;CS-0314315;SR-01000370496;SR-01000370496-1;1-[2-(2-methoxy-phenoxy)-ethyl]-piperazine, AldrichCPR

Chemical Property of 1-[2-(2-Methoxy-phenoxy)-ethyl]-piperazine

Chemical Property:

• PSA: 33.73000
• LogP: 1.24590
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 236.152477885
• Heavy Atom Count: 17
• Complexity: 208

Purity/Quality:

98%min ^*data from raw suppliers

1-[2-(2-Methoxy-phenoxy)-ethyl]-piperazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1OCCN2CCNCC2

Technology Process of 1-[2-(2-Methoxy-phenoxy)-ethyl]-piperazine

There total 2 articles about 1-[2-(2-Methoxy-phenoxy)-ethyl]-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine (110-85-0) + 2-(methoxyphenoxy)ethylbromide (4463-59-6) → 4-<2-(2-methoxyphenoxy)ethyl>piperazine (117132-45-3)

Guidance literature:

In acetonitrile; Reflux;

DOI:10.1016/j.cclet.2009.11.030

Reference yield:

→ 4-<2-(2-methoxyphenoxy)ethyl>piperazine (117132-45-3)

Guidance literature:

entspr. Formyl-verb., EtOH/Soda;

Reference yield: 37.6%

2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-chloroethyl)ester-5-methyl ester (54527-89-8) + 4-<2-(2-methoxyphenoxy)ethyl>piperazine (117132-45-3) → 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ester 2-(N-4-(2-(2-methoxyphenoxy)ethyl)piperazinyl)ethyl ester hydrochloride

Guidance literature:

2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-chloroethyl)ester-5-methyl ester; 4-<2-(2-methoxyphenoxy)ethyl>piperazine; With sodium hydroxide; In acetonitrile; at 60 ℃; for 1h;

With hydrogenchloride; In diethyl ether; at 20 ℃; pH=2;

upstream raw materials:

piperazine

2-(methoxyphenoxy)ethylbromide

Downstream raw materials:

4-chloro-5-<4-(2-methoxyphenoxyethyl)-1-piperazinyl>-3(2H)-pyridazinone

4-<4-(2-methoxyphenoxyethyl)-1-piperazinyl>-5-chloro-3(2H)-pyridazinone

2-methyl-4-chloro-5-<4-(2-methoxyphenoxyethyl)-1-piperazinyl>-3(2H)-pyridazinone

4-chloro-2-(7-bromoheptyl)-5-<4-<2-(2-methoxyphenoxy)ethyl>-1-piprazinyl>-3(2H)-pyridazinone