2,3-Dibromo-5,6-dimethylpyridine

Base Information

• Chemical Name: 2,3-Dibromo-5,6-dimethylpyridine
• CAS No.: 117846-56-7
• Molecular Formula: C7H7Br2N
• Molecular Weight: 264.94500
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID60554059
• Wikidata: Q72464234
• Mol file: 117846-56-7.mol

Synonyms:2,3-Dibromo-5,6-dimethylpyridine;117846-56-7;5,6-DIBROMO-2,3-DIMETHYLPYRIDINE;MFCD13688994;Pyridine, 2,3-dibromo-5,6-dimethyl-;2,3-dibromo-5,6-dimethyl-pyridine;SCHEMBL23888235;DTXSID60554059;AKOS016005053;AS-61029;SY320500;CS-0061216;EN300-203819;W17922

Chemical Property of 2,3-Dibromo-5,6-dimethylpyridine

Chemical Property:

• PSA: 12.89000
• LogP: 3.22340
• Storage Temp.: 2-8°C
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 264.89247
• Heavy Atom Count: 10
• Complexity: 118

Purity/Quality:

98% ^*data from raw suppliers

2,3-Dibromo-5,6-dimethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(N=C1C)Br)Br

Technology Process of 2,3-Dibromo-5,6-dimethylpyridine

There total 3 articles about 2,3-Dibromo-5,6-dimethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

2,3-Lutidine (583-61-9) → 2,3-dibromo-5,6-dimethylpyridine (117846-56-7) + 3-bromo-5,6-dimethylpyridine (27063-90-7)

Guidance literature:

With sulfuric acid; bromine; at 155 - 175 ℃; for 24h;

Reference yield:

3-bromo-5,6-dimethylpyridin-2-ol → 2,3-dibromo-5,6-dimethylpyridine (117846-56-7)

Guidance literature:

With phosphorus(V) oxybromide; In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide; toluene; at 90 ℃; Inert atmosphere;

Reference yield:

2-amino-3-bromo-5,6-dimethylpyridine (161091-49-2) → 2,3-dibromo-5,6-dimethylpyridine (117846-56-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium nitrite; sulfuric acid / water / 2.5 h / 0 - 25 °C

1.2: 20 °C

2.1: phosphorus(V) oxybromide / toluene; N,N-dimethyl-formamide; 5,5-dimethyl-1,3-cyclohexadiene / 90 °C / Inert atmosphere

With sulfuric acid; sodium nitrite; phosphorus(V) oxybromide; In 5,5-dimethyl-1,3-cyclohexadiene; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

2,3-Lutidine

2-amino-3-bromo-5,6-dimethylpyridine

Refernces

• 1、 -. "METHODS OF USING MYT1 INHIBITORS". . . Retrieved 2021/10/11.