5-PIPERAZIN-1-YL-QUINOLINE

Base Information

• Chemical Name: 5-PIPERAZIN-1-YL-QUINOLINE
• CAS No.: 117922-84-6
• Molecular Formula: C13H15N3
• Molecular Weight: 213.282
• Mol file: 117922-84-6.mol

Synonyms:1-(5-quinolyl)piperazine;5-(piperazin-1-yl)quinoline;5-piperazin-1-yl-quinoline;5-(1-Piperazinyl)-quinoline;5-(1-piperazinyl)quinoline;5-(piperazin-1-yl)-quinoline;

Chemical Property of 5-PIPERAZIN-1-YL-QUINOLINE

Chemical Property:

• PSA: 28.16000
• LogP: 2.03820

Purity/Quality:

99% ^*data from raw suppliers

5-(1-piperazinyl)-Quinoline 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-PIPERAZIN-1-YL-QUINOLINE

There total 4 articles about 5-PIPERAZIN-1-YL-QUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-(quinolin-5-yl)piperazine-1-carboxylate (282547-37-9) → 5-(1-piperazinyl)-quinoline (117922-84-6)

Guidance literature:

With trifluoroacetic acid; In methanol; dichloromethane; at 0 - 20 ℃;

Reference yield: 33.0%

→ 5-(1-piperazinyl)-quinoline (117922-84-6)

Guidance literature:

With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate; In para-xylene; toluene; at 120 ℃; for 1h; Microwave irradiation; Inert atmosphere;

Reference yield: 23.0%

5-Aminoquinoline (611-34-7,146614-41-7) + bis-(2-chloroethyl)amine hydrochloride (821-48-7) → 5-(1-piperazinyl)-quinoline (117922-84-6)

Guidance literature:

With potassium carbonate; In chlorobenzene; for 24h; Heating;

DOI:10.1021/jm0111200

upstream raw materials:

5-Aminoquinoline

bis-(2-chloroethyl)amine hydrochloride

tert-butyl 4-(quinolin-5-yl)piperazine-1-carboxylate

5-bromoquinoline