2-[4-(Propan-2-yl)phenyl]imidazo[1,2-a]pyridine

Base Information

• Chemical Name: 2-[4-(Propan-2-yl)phenyl]imidazo[1,2-a]pyridine
• CAS No.: 118000-47-8
• Molecular Formula: C16H16N2
• Molecular Weight: 236.31200
• DSSTox Substance ID: DTXSID00357369
• Wikidata: Q82137261
• Mol file: 118000-47-8.mol

Synonyms:118000-47-8;2-[4-(Propan-2-yl)phenyl]imidazo[1,2-a]pyridine;2-(4-isopropylphenyl)imidazo[1,2-a]pyridine;2-(4-propan-2-ylphenyl)imidazo[1,2-a]pyridine;SCHEMBL2739322;DTXSID00357369;AKOS017271260;AQ-776/42801667;imidazo[1,2-a]pyridine,2-[4-(1-methylethyl)phenyl]-

Chemical Property of 2-[4-(Propan-2-yl)phenyl]imidazo[1,2-a]pyridine

Chemical Property:

• PSA: 17.30000
• LogP: 4.12470
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 236.131348519
• Heavy Atom Count: 18
• Complexity: 268

Purity/Quality:

99.90% ^*data from raw suppliers

2-[4-(1-METHYLETHYL)PHENYL]-IMIDAZO[1,2-A]PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C1=CC=C(C=C1)C2=CN3C=CC=CC3=N2

Technology Process of 2-[4-(Propan-2-yl)phenyl]imidazo[1,2-a]pyridine

There total 2 articles about 2-[4-(Propan-2-yl)phenyl]imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-aminopyridine (504-29-0) + α-bromomethyl 4-isopropylphenyl ketone (51012-62-5) → 2-(4-iso-propylphenyl)imidazo[1,2-a]pyridine (118000-47-8)

Guidance literature:

With hydrogen bromide; Yield given. Multistep reaction; 1) acetone, reflux, 3 h, 2) methanol, reflux, 60 min;

DOI:10.1002/jhet.5570250119

Reference yield:

→ 2-(4-iso-propylphenyl)imidazo[1,2-a]pyridine (118000-47-8)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; at 80 ℃; for 5h;

Reference yield: 81.0%

iodotrifluoromethane (2314-97-8,263005-66-9) + 2-(4-iso-propylphenyl)imidazo[1,2-a]pyridine (118000-47-8) → C17H15F3N2

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In 1,4-dioxane; at 60 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201600702

upstream raw materials:

2-aminopyridine

α-bromomethyl 4-isopropylphenyl ketone