Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1)

Base Information

• Chemical Name: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1)
• CAS No.: 118352-74-2
• Molecular Formula: C37H36N3O9P.C6H15N
• Molecular Weight: 798.873

Synonyms:

Chemical Property of Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1)

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1)

There total 5 articles about Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) + triethylamine (121-44-8) + Ammonium 4-methylphenyl H-phosphonate → 5'-O-(4,4'-dimethoxytrityl)-4-N-benzoyl-2'-deoxycytidine-3'-H-phosphonate triethylammonium salt (118352-74-2)

Guidance literature:

triethylamine; Ammonium 4-methylphenyl H-phosphonate; With pyridine;

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine; With pyridine; pivaloyl chloride; at -35 ℃; for 0.5h;

Reference yield: 57.8%

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) + triethylamine (121-44-8) → 5'-O-(4,4'-dimethoxytrityl)-4-N-benzoyl-2'-deoxycytidine-3'-H-phosphonate triethylammonium salt (118352-74-2)

Guidance literature:

With bis(trichloromethyl) carbonate; phosphonic acid; In acetonitrile; at 0 ℃; for 4h;

DOI:10.1016/0040-4039(95)01383-S

Reference yield:

C44H42N3O9P → 5'-O-(4,4'-dimethoxytrityl)-4-N-benzoyl-2'-deoxycytidine-3'-H-phosphonate triethylammonium salt (118352-74-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O, pyridine / 1 h / Ambient temperature

2: H₂O; CH₂Cl₂ / pH 7.0

With pyridine; water; In dichloromethane; water;

DOI:10.1016/0040-4039(96)01993-4

upstream raw materials:

triethylamine

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

Downstream raw materials:

(R_P)-N⁴-benzoyl-5'-O-(4,4-dimethoxytrityl)-2'-deoxycytidylyl-(3'->5')-N⁶-benzoyl-3'-O-<1,1-dimethylethyl)dimethylsilyl>-2'-deoxyadenosine 3'-H-phosphonate

(S_P)-N⁴-benzoyl-5'-O-(4,4-dimethoxytrityl)-2'-deoxycytidylyl-(3'->5')-N⁶-benzoyl-3'-O-<1,1-dimethylethyl)dimethylsilyl>-2'-deoxyadenosine 3'-H-phosphonate

C₄₃H₃₇Cl₃N₃O₉P

C₅₂H₅₄N₅O₁₅P

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