Technology Process of Diethyl ethyl[(3-nitrophenyl)methyl]propanedioate
There total 1 articles about Diethyl ethyl[(3-nitrophenyl)methyl]propanedioate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydride;
Multistep reaction;
1.) ethyl ether, reflux, 2.) ethyl ether, RT, 6 h;
DOI:10.1016/S0957-4166(00)86152-2
- Guidance literature:
-
Multi-step reaction with 7 steps
1: aq. KOH / ethanol / 24 h / Heating
2: dimethylformamide / 4 h / 100 - 110 °C
3: HCl / 24 h / Ambient temperature
4: 100 percent / H2 / 5percent Pd/C / methanol / Ambient temperature
5: 0.42 g
6: 0.1 M potassium phosphate buffer (pH 7.8) / 24 h / Ambient temperature; horse liver esterase
7: iodine monochloride, 6percent aq. HCl / 1 h / 70 °C
With
hydrogenchloride; potassium hydroxide; potassium phosphate buffer; hydrogen; Iodine monochloride;
palladium on activated charcoal;
In
methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(00)86152-2
- Guidance literature:
-
Multi-step reaction with 6 steps
1: aq. KOH / ethanol / 24 h / Heating
2: dimethylformamide / 4 h / 100 - 110 °C
3: HCl / 24 h / Ambient temperature
4: 100 percent / H2 / 5percent Pd/C / methanol / Ambient temperature
5: 0.42 g
6: 0.256 g / aq. H2SO4, aq. sodium nitrite, 50percent aq. H3PO2 / 48 h / 0 °C
With
hydrogenchloride; potassium hydroxide; sulfuric acid; hydrogen; hypophosphorous acid; sodium nitrite;
palladium on activated charcoal;
In
methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(00)86152-2
