2-Methoxyethyl-malonic acid dibenzyl ester

Base Information

Chemical Name:2-Methoxyethyl-malonic acid dibenzyl ester
CAS No.:118786-37-1
Molecular Formula:C20H22O5
Molecular Weight:342.392
Hs Code.:
DSSTox Substance ID:DTXSID901212380
Mol file:118786-37-1.mol

Synonyms:SCHEMBL9470496;ODKWKFQXXFYPLN-UHFFFAOYSA-N;DTXSID901212380;2-methoxyethyl-malonic acid dibenzyl ester;1,3-Bis(phenylmethyl) 2-(2-methoxyethyl)propanedioate;118786-37-1

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Methoxyethyl-malonic acid dibenzyl ester

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:11
Exact Mass:342.14672380
Heavy Atom Count:25
Complexity:363

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COCCC(C(=O)OCC1=CC=CC=C1)C(=O)OCC2=CC=CC=C2

Technology Process of 2-Methoxyethyl-malonic acid dibenzyl ester

There total 1 articles about 2-Methoxyethyl-malonic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 15014-25-2
malonic acid dibenzyl ester

: 6482-24-2
2-Bromoethyl methyl ether

: 118786-37-1
2-(2-methoxyethyl)malonic acid dibenzyl ester

Guidance literature:: malonic acid dibenzyl ester; With sodium hydride; In tetrahydrofuran; at 20 - 40 ℃; for 1h;

2-Bromoethyl methyl ether; In tetrahydrofuran; for 16h; Heating;
DOI:10.1016/j.bmc.2006.10.002

Reference yield: 46.0%

: 118786-37-1
2-(2-methoxyethyl)malonic acid dibenzyl ester

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 118786-24-6
4-methoxy-2-methylenebutyric acid benzyl ester

Guidance literature:: 2-(2-methoxyethyl)malonic acid dibenzyl ester; With potassium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 16h;

formaldehyd; With piperidine; In pyridine; at 60 ℃; for 3h;
DOI:10.1016/j.bmc.2006.10.002

Reference yield:

: 118786-37-1
2-(2-methoxyethyl)malonic acid dibenzyl ester

: 4-methoxy-2-(1-phenethylcarbamoyl-cyclopentylmethyl)-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: KOH / dioxane; H₂O / 16 h / 20 °C

1.2: 46 percent / piperidine / pyridine / 3 h / 60 °C

2.1: LDA / hexane; tetrahydrofuran / 2.5 h / -30 - 20 °C

2.2: 34 percent / tetrahydrofuran; hexane / 2 h / -78 °C

3.1: 65 percent / 1-hydroxybenzotriazole; N-methylmorpholine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / CH₂Cl₂ / 12 h / 20 °C

4.1: 68 percent / H₂ / Pd/C / ethanol / 3 h / 775.72 Torr

With 4-methyl-morpholine; potassium hydroxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; water;
DOI:10.1016/j.bmc.2006.10.002