6-Phenylhexylamine, Hydrochloride

Base Information

• Chemical Name: 6-Phenylhexylamine, Hydrochloride
• CAS No.: 120375-57-7
• Molecular Formula: C₁₂H₁₉N*ClH
• Molecular Weight: 213.75
• Mol file: 120375-57-7.mol

Synonyms:Benzenehexanamine,Hydrochloride;6-Phenylhexylamine Hydrochloride;

Chemical Property of 6-Phenylhexylamine, Hydrochloride

Chemical Property:

• Vapor Pressure: 0.00324mmHg at 25°C
• Melting Point: 112-116°C (dec.)
• Boiling Point: 283oC at 760 mmHg
• Flash Point: 122.7oC
• PSA: 26.02000
• LogP: 4.25050
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility.: DMSO, Methanol

Purity/Quality:

98%Min ^*data from raw suppliers

6-PhenylhexylamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Phenylhexylamine Hydrochloride (cas# 120375-57-7) is a compound useful in organic synthesis.

Technology Process of 6-Phenylhexylamine, Hydrochloride

There total 5 articles about 6-Phenylhexylamine, Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H27N → 6-phenylhexan-1-amine hydrochloride (120375-57-7)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In ethanol; water; at 65 ℃; for 14h;

DOI:10.1016/j.tetlet.2009.02.129

Reference yield:

2-(6-phenylhexyl)-1,3-dihydro-1,3-dioxo-2H-isoindole (138619-78-0) → 6-phenylhexan-1-amine hydrochloride (120375-57-7)

Guidance literature:

2-(6-phenylhexyl)-1,3-dihydro-1,3-dioxo-2H-isoindole; With hydrazine hydrate; In ethanol; at 78 ℃; for 3h;

With hydrogenchloride; In water;

DOI:10.1021/acs.jmedchem.5b01188

Reference yield:

6-phenyl-1-hexanol (2430-16-2) → 6-phenylhexan-1-amine hydrochloride (120375-57-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

2.1: hydrazine hydrate / ethanol / 3 h / 78 °C

2.2: Gabriel Amine Synthesis

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; toluene; 2.1: |Gabriel Amine Synthesis;

DOI:10.1021/acs.jmedchem.5b01188

upstream raw materials:

6-phenyl-1-hexanol

6-phenylhexanic acid

2-(6-phenylhexyl)-1,3-dihydro-1,3-dioxo-2H-isoindole

Refernces

• 1、 -. "SUBSTITUTED BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS". Page/Page column 19; 39; 46. . Retrieved 2015/12/31.
• 2、 Lamb, Gareth W.,Watson, Andrew J.A.,Jolley, Katherine E.,Maxwell, Aoife C.,Williams, Jonathan M.J.. "Borrowing hydrogen methodology for the conversion of alcohols into N-protected primary amines and in situ deprotection". experimental part. p. 3374 - 3377. Retrieved 2009/09/05.