Technology Process of 5-Hydroxycyclooctanone
There total 2 articles about 5-Hydroxycyclooctanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridinium chlorochromate;
In
dichloromethane;
at 20 ℃;
for 4h;
DOI:10.1021/ja043002i
- Guidance literature:
-
Cyclooctan, O2, Schwermetall-Katal., Co-Naphthenat, 120grad;
- Guidance literature:
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Multi-step reaction with 5 steps
1: 86 percent / ethanol / 2 h / Heating
2: 86 percent / SeO2 / dioxane; H2O / Ambient temperature
3: 1) n-BuLi, 2) MeI / 1) THF, n-hexane, -60 deg C, 1h, 2) r.t., 30 min
4: 90 percent / py
5: 53 percent Chromat. / 75percent aq. EtOH, Et3N / 528 h / 75 °C / further reagent: 50percent aq. EtOH; var. times
With
pyridine; n-butyllithium; selenium(IV) oxide; ethanol; triethylamine; methyl iodide;
In
1,4-dioxane; ethanol; water;
