1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL

Base Information

• Chemical Name: 1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL
• CAS No.: 120964-49-0
• Molecular Formula: C20H42O3
• Molecular Weight: 330.54600
• Mol file: 120964-49-0.mol

Synonyms:3-O-Hexadecyl-2-O-methyl-sn-glycerol;

Chemical Property of 1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL

Chemical Property:

• Melting Point: 29-30 °C
• Boiling Point: 430.6±25.0 °C(Predicted)
• PKA: 14.20±0.10(Predicted)
• PSA: 38.69000
• Density: 0.895±0.06 g/cm3(Predicted)
• LogP: 5.49160
• Storage Temp.: −20°C

Purity/Quality:

99%,98%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-O-Hexadecyl-2-O-methyl-sn-glycerol inhibits protein kinase C activity in human neutrophils.

Technology Process of 1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL

There total 13 articles about 1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-O-hexadecyl-2-O-methyl-1-O-(tert-butyldiphenylsilyl)-sn-glycerol (122822-35-9) → (-)-1-O-hexadecyl-2-O-methyl-sn-glycerol (120964-49-0,111188-59-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1021/jo00280a034

Reference yield: 93.0%

3-O-Hexadecyl-2-O-methyl-1-O-(4-methoxyphenyl)-sn-glycerol (156737-70-1) → (-)-1-O-hexadecyl-2-O-methyl-sn-glycerol (120964-49-0,111188-59-1)

Guidance literature:

With ammonium cerium(IV) nitrate; In water; acetonitrile; for 4h; Ambient temperature;

DOI:10.1021/jo00088a059

Reference yield: 89.0%

3-O-hexadecyl-2-O-methyl-1-O-(p-tolylsulfonyl)-sn-glycerol (122822-33-7) → (-)-1-O-hexadecyl-2-O-methyl-sn-glycerol (120964-49-0,111188-59-1)

Guidance literature:

With potassium superoxide; 18-crown-6 ether; In 1,2-dimethoxyethane; dimethyl sulfoxide; N,N-dimethyl-formamide; for 6h; Ambient temperature;

DOI:10.1021/jo00280a034

upstream raw materials:

3-O-hexadecyl-2-O-methyl-1-O-(p-tolylsulfonyl)-sn-glycerol

3-O-hexadecyl-2-O-methyl-1-O-(tert-butyldiphenylsilyl)-sn-glycerol

3-O-Hexadecyl-2-O-methyl-1-O-(4-methoxyphenyl)-sn-glycerol

hexadecanyl bromide