difluoromethylene diphosphonate

Base Information

• Chemical Name: difluoromethylene diphosphonate
• CAS No.: 10596-32-4
• Molecular Formula: CH4 F2 O6 P2
• Molecular Weight: 211.983
• Hs Code.: 2931900090
• Mol file: 10596-32-4.mol

Synonyms:Phosphonicacid, (difluoromethylene)bis- (9CI); Phosphonic acid, (difluoromethylene)di-(8CI); (Difluoromethylene)bis[phosphonic acid]; Difluoromethylenediphosphonicacid

Chemical Property of difluoromethylene diphosphonate

Chemical Property:

• Vapor Pressure: 3.16E-10mmHg at 25°C
• Melting Point: 87-90 °C
• Boiling Point: 472.4°Cat760mmHg
• PKA: 0.48±0.10(Predicted)
• Flash Point: 239.5°C
• PSA: 134.68000
• Density: 2.247g/cm³
• LogP: -0.10790
• Storage Temp.: -20°C Freezer

Purity/Quality:

98%,99%, ^*data from raw suppliers

DifluoromethylenediphosphonicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A phosphonic acid derivative for development of biologically active compounds.

Technology Process of difluoromethylene diphosphonate

There total 1 articles about difluoromethylene diphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H14F2N2O14P3(1-) + α-D-glucopyranosyl-1-phosphate (59-56-3,27251-84-9,63779-58-8,262856-84-8) → UDP-glucose (133-89-1) + [difluoro(phosphono)methyl]phosphonic acid (10596-32-4)

Guidance literature:

With Cps₂L thymidylyltransferase cloned from Streptococcus pneumoniae; inorganic phosphatase; magnesium chloride; In aq. buffer; pH=7.4; Kinetics; Enzymatic reaction;

DOI:10.1039/c3ob41017j

Reference yield:

[difluoro(phosphono)methyl]phosphonic acid (10596-32-4) + C10H12Cl2N5O5P (34051-17-7) → 2-propylthioadenosine-5'-(β,γ-difluoromethylene)triphosphonate (81336-78-9)

Guidance literature:

[difluoro(phosphono)methyl]phosphonic acid; With tributyl-amine; In ethanol; water; pH=7 - 8;

C₁₀H₁₂Cl₂N₅O₅P; With tributyl-amine; In N,N-dimethyl-formamide; Inert atmosphere; Cooling;

With water; In N,N-dimethyl-formamide; at 20 ℃; for 1h; pH=7.4 - 7.6; Cooling; Inert atmosphere;

DOI:10.3389/fphar.2020.01294

Reference yield:

[difluoro(phosphono)methyl]phosphonic acid (10596-32-4) → difluoromethylenebisphosphonic acid disodium salt (84228-60-4,89732-98-9)

Guidance literature:

With sodium hydroxide;

DOI:10.1016/S0022-1139(00)82287-3

upstream raw materials:

α-D-glucopyranosyl-1-phosphate

Downstream raw materials:

difluoromethylenebisphosphonic acid disodium salt

2-propylthioadenosine-5'-(β,γ-difluoromethylene)triphosphonate

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