2-Methoxy-4-(4-methylpiperazin-1-yl)aniline

Base Information

Chemical Name:2-Methoxy-4-(4-methylpiperazin-1-yl)aniline
CAS No.:122833-04-9
Molecular Formula:C12H19N3O
Molecular Weight:221.302
Hs Code.:2933599090
European Community (EC) Number:887-568-0
DSSTox Substance ID:DTXSID90602870
Wikidata:Q72490629
Mol file:122833-04-9.mol

Synonyms:2-Methoxy-4-(4-methylpiperazin-1-yl)aniline;122833-04-9;Benzenamine, 2-methoxy-4-(4-methyl-1-piperazinyl)-;2-Methoxy-4-(4-methyl-1-piperazinyl)aniline;1-(4-AMINO-3-METHOXYPHENYL)-4-METHYLPIPERAZINE;MFCD11848954;BENZENAMINE, 2-METHOXY-4-(4-METHYL-1-PIPERAZINYL);SCHEMBL438444;DTXSID90602870;LUYPGLRYFIVYTH-UHFFFAOYSA-N;BCP18177;CS-M2488;SC5116;AKOS012981420;NCGC00386579-01;AC-27545;AM803055;DS-13525;SY047070;DB-062100;EN300-298695;2-methoxy-4-(4-methylpiperazin-1-yl)benzenamine;A890942;2-methoxy-4-(4-methyl-piperazin-1-yl)-phenylamine;J-509799

Suppliers and Price of 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(4-Amino-3-methoxyphenyl)-4-methylpiperazine
5 g
$ 495.00

TRC
1-(4-Amino-3-methoxyphenyl)-4-methylpiperazine
250mg
$ 65.00

Oakwood
2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 97%
1g
$ 59.00

Oakwood
2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 97%
250mg
$ 30.00

Oakwood
2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 97%
5g
$ 179.00

Oakwood
2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 97%
10g
$ 299.00

Medical Isotopes, Inc.
2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 97%
10 g
$ 673.00

Matrix Scientific
2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 97%
1g
$ 250.00

Matrix Scientific
2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 97%
5g
$ 475.00

Matrix Scientific
2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 97%
10g
$ 850.00

Total 44 raw suppliers

Chemical Property of 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline

Chemical Property:

Vapor Pressure:0.0±0.9 mmHg at 25°C
Boiling Point:392℃
PKA:7.78±0.42(Predicted)
Flash Point:191℃
PSA：41.73000
Density:1.111
LogP:1.61330
Storage Temp.:2-8°C(protect from light)
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:221.152812238
Heavy Atom Count:16
Complexity:216

Purity/Quality:

99%, ^*data from raw suppliers

1-(4-Amino-3-methoxyphenyl)-4-methylpiperazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C2=CC(=C(C=C2)N)OC
Uses 1-(4-Amino-3-methoxyphenyl)-4-methylpiperazine is a useful synthetic intermediate. It is used to 4,5-dihydro-1H-pyrazolo[4,3-h]quinazolines as orally and selective Polo-like kinase 1 inhibitors. It is also used to synthesize IRAK-4 inhibitors.

Technology Process of 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline

There total 12 articles about 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 761440-26-0
2-methoxy-4-(4-methyl piperazin-1-yl)nitrobenzene

: 122833-04-9
2-methoxy-4-(4-methylpiperazin-1-yl)aniline

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; for 2h;

Reference yield: 94.0%

: 122833-04-9
2-methoxy-4-(4-methylpiperazin-1-yl)aniline

Guidance literature:: With palladium 10% on activated carbon; In ethanol; at 20 ℃; for 0.25h; Inert atmosphere;

With ammonium formate; In ethanol; for 0.25h; Reflux;

Reference yield: 85.0%

: 109-01-3
1-methyl-piperazine

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 122833-04-9
2-methoxy-4-(4-methylpiperazin-1-yl)aniline

Guidance literature:: 1-methyl-piperazine; 4-fluoro-2-methoxy-1-nitrobenzene; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 18h;

With hydrogen; In methanol; at 20 ℃; for 5h;