3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(6-methylimidazo[2,1-b]thi azol-5-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester

Base Information

Chemical Name:3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(6-methylimidazo[2,1-b]thi azol-5-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester
CAS No.:122956-97-2
Molecular Formula:C₃₃H₂₈ClN₅O₃S
Molecular Weight:610.136
Hs Code.:
Mol file:122956-97-2.mol

3-Pyridinecarboxylic acid,
4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(6-methylimidazo[2,1-b]thi
azol-5-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester

Synonyms:

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Chemical Property of 3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(6-methylimidazo[2,1-b]thi azol-5-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester

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Technology Process of 3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(6-methylimidazo[2,1-b]thi azol-5-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester

There total 4 articles about 3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(6-methylimidazo[2,1-b]thi azol-5-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 89-98-5
2-chloro-benzaldehyde

: 60155-47-7
N-(2-pyridyl)-3-aminocrotonamide

: 122957-23-7
3-[4-(6-Methyl-imidazo[2,1-b]thiazol-5-yl)-phenyl]-3-oxo-propionic acid ethyl ester

: 122956-97-2
4-(2-Chloro-phenyl)-6-methyl-2-[4-(6-methyl-imidazo[2,1-b]thiazol-5-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

Guidance literature:: With acetic acid; In ethanol; for 8h; Heating;
DOI:10.1021/jm00095a005

Reference yield:

: 58949-75-0
4-(2-oxopropyl)benzonitrile

: 122956-97-2
4-(2-Chloro-phenyl)-6-methyl-2-[4-(6-methyl-imidazo[2,1-b]thiazol-5-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / Br₂ / CH₂Cl₂ / 0.5 h / 25 °C

2: 35 percent / Et₃N / butan-1-ol / 2 h / 100 °C

3: 1.) Zn, 2.) 20percent aq. TFA / 1.) THF, reflux, 10 min, 2.) CH₂Cl₂, RT, 15 min

4: 6 percent / glacial AcOH / ethanol / 8 h / Heating

With bromine; acetic acid; triethylamine; trifluoroacetic acid; zinc; In ethanol; dichloromethane; butan-1-ol;
DOI:10.1021/jm00095a005

Reference yield:

: 122957-58-8
1-bromo-1-(4-cyanophenyl)-2-oxopropane

: 122956-97-2
4-(2-Chloro-phenyl)-6-methyl-2-[4-(6-methyl-imidazo[2,1-b]thiazol-5-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / Et₃N / butan-1-ol / 2 h / 100 °C

2: 1.) Zn, 2.) 20percent aq. TFA / 1.) THF, reflux, 10 min, 2.) CH₂Cl₂, RT, 15 min

3: 6 percent / glacial AcOH / ethanol / 8 h / Heating

With acetic acid; triethylamine; trifluoroacetic acid; zinc; In ethanol; butan-1-ol;
DOI:10.1021/jm00095a005