Benzeneethanol, b-butyl-, (S)-

Base Information

• Chemical Name: Benzeneethanol, b-butyl-, (S)-
• CAS No.: 123126-66-9
• Molecular Formula: C₁₂H₁₈O
• Molecular Weight: 178.274
• Mol file: 123126-66-9.mol

Synonyms:

Chemical Property of Benzeneethanol, b-butyl-, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneethanol, b-butyl-, (S)-

There total 4 articles about Benzeneethanol, b-butyl-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-di-tert-butyl-4-methylphenyl 2-phenylhexanoate (1016625-40-3) → (S)-2-phenylhexanol (123126-66-9)

Guidance literature:

With lithium aluminium tetrahydride; Inert atmosphere;

DOI:10.1021/ja805165y

Reference yield:

chlorobromomethane (74-97-5) + 4,4,5,5-tetramethyl-2-(1-phenylpentyl)-1,3,2-dioxaborolane (1037742-95-2) → (R)-2-phenylhexan-1-ol (185130-35-2) + (S)-2-phenylhexanol (123126-66-9)

Guidance literature:

chlorobromomethane; 4,4,5,5-tetramethyl-2-(1-phenylpentyl)-1,3,2-dioxaborolane; With n-butyllithium; In diethyl ether; hexane; at -78 - 20 ℃; for 2h; Inert atmosphere; Cooling with acetone-dry ice;

With dihydrogen peroxide; sodium hydroxide; In methanol; diethyl ether; water; at 20 ℃; Overall yield = 88 %; Overall yield = 63 mg; Optical yield = 88 %ee; Inert atmosphere;

DOI:10.1002/anie.201806015

Reference yield:

Acetic acid (S)-2-phenyl-hexyl ester (185130-36-3) → (S)-2-phenylhexanol (123126-66-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 6h; Heating;

DOI:10.1016/0957-4166(96)00429-6

upstream raw materials:

Acetic acid (S)-2-phenyl-hexyl ester

2-benzene-2-butylethanol

2,6-di-tert-butyl-4-methylphenyl 2-phenylhexanoate

chlorobromomethane

Refernces

• 1、 Smith, Sean W.,Fu, Gregory C.. "Nickel-catalyzed asymmetric cross-couplings of racemic propargylic halides with arylzinc reagents". supporting information; scheme or table. p. 12645 - 12647. Retrieved 2009/05/09.