Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(2-oxo-2-phenylethyl)-2-[[(1S,4R)-4, 7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]hept-1-yl]carbonyl]-, (1S)-

Base Information

Chemical Name:Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(2-oxo-2-phenylethyl)-2-[[(1S,4R)-4, 7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]hept-1-yl]carbonyl]-, (1S)-
CAS No.:123279-29-8
Molecular Formula:C₂₉H₃₃NO₆
Molecular Weight:491.584
Hs Code.:

Isoquinoline,
1,2,3,4-tetrahydro-6,7-dimethoxy-1-(2-oxo-2-phenylethyl)-2-[[(1S,4R)-4,
7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]hept-1-yl]carbonyl]-, (1S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(2-oxo-2-phenylethyl)-2-[[(1S,4R)-4, 7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]hept-1-yl]carbonyl]-, (1S)-

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Technology Process of Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(2-oxo-2-phenylethyl)-2-[[(1S,4R)-4, 7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]hept-1-yl]carbonyl]-, (1S)-

There total 1 articles about Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(2-oxo-2-phenylethyl)-2-[[(1S,4R)-4, 7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]hept-1-yl]carbonyl]-, (1S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13735-81-4
1-styrenyloxytrimethylsilane

: 6,7-Dimethoxy-2-<(1S,4R)-4,7,7-trimethyl-3-oxo-2-oxa-1-bicyclo<2.2.1>-heptylcarbonyl>-3,4-dihydroisoquinolinium-tetrafluoroborate

: 123355-78-2
(1S,4R)-1-<(1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-oxo-2-phenyl-1-ethyl)-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

: 123279-29-8
(1S,4R)-1-<(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-oxo-2-phenyl-1-ethyl)-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

Guidance literature:: at -90 ℃; for 2h; also with TiCl₄ ; other silyl enol ethers and a silicon reagent;
DOI:10.1002/ardp.19903230605

Reference yield: 59.1%

: 123279-29-8,123355-78-2
(1S,4R)-1-<1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-oxo-2-phenyl-1-ethyl)-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

: 129958-89-0
(1S,4R)-1-<(1R)-1-(2-Cyclohexyl-1-ethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

: 123355-81-7
(1S,4R)-1-<(1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-phenyl-1-ethyl)-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

: 123279-32-3
(1S,4R)-1-<(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-phenyl-1-ethyl)-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

Guidance literature:: With hydrogen; 10% palladium on active carbon; In acetic acid; trifluoroacetic acid; for 24h; under 2250.2 Torr; Ambient temperature;
DOI:10.1002/ardp.19903230605

Reference yield:

: 123279-29-8,123355-78-2
(1S,4R)-1-<1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-oxo-2-phenyl-1-ethyl)-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

: 129958-90-3
(1S,3R)-1-<(1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-phenyl-1-ethyl)-2-isoquinolyl-methyl>-3-hydroxymethyl-2,2,3-trimethyl-1-cyclopentanol

Guidance literature:: Multi-step reaction with 2 steps

1: 59.1 percent / H₂ / Pd/C (10percent Pd) / acetic acid; trifluoroacetic acid / 24 h / 2250.2 Torr / Ambient temperature

2: 30.4 percent / LiAlH₄ / tetrahydrofuran / 3 h / Ambient temperature

With lithium aluminium tetrahydride; hydrogen; 10% palladium on active carbon; In tetrahydrofuran; acetic acid; trifluoroacetic acid;
DOI:10.1002/ardp.19903230605