17(S)-HpDoHE

Base Information

• Chemical Name: 17(S)-HpDoHE
• CAS No.: 123673-33-6
• Molecular Formula: C22H32O4
• Molecular Weight: 360.48700
• Mol file: 123673-33-6.mol

Synonyms:17S-H(p)DHA;4,5-dehydro-17S-H(p)DHA;17(S)-HpDoHE;

Chemical Property of 17(S)-HpDoHE

Chemical Property:

• PSA: 66.76000
• LogP: 6.01700

Purity/Quality:

99.90% ^*data from raw suppliers

17(S)-HpDHA ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: 17(S)-HpDHA is a mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, human glial cells, and mouse brain. 17(S)-HpDHA is generally reduced to 17(S)-HDHA , a compound that serves as a precursor to 17(S)-resolvins. 17(S)-HDHA has been shown to inhibit TNF-α-induced interleukin-1β expression in human glioma cells and inhibit TNF-α-induced leukocyte trafficking to the murine air pouch.

Technology Process of 17(S)-HpDoHE

There total 2 articles about 17(S)-HpDoHE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,5-dehydro-DHA (149234-03-7) → 17(S)-hydroperoxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid (123673-33-6)

Guidance literature:

With 15- lipoxyenase; at 0 - 4 ℃; for 0.5 - 0.666667h; pH=9.2; Borate buffer;

Reference yield:

docosahexaenoic acid (6217-54-5) → 17(S)-hydroperoxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid (123673-33-6)

Guidance literature:

With 15-lipoxygenase soybean;

Reference yield:

17(S)-hydroperoxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid (123673-33-6) → (17S)-HDHA (92693-03-3)

Guidance literature:

With sodium tetrahydroborate;

upstream raw materials:

4,5-dehydro-DHA

docosahexaenoic acid

Downstream raw materials:

(17S)-HDHA