NH-(m-PEG4)2

Base Information

• Chemical Name: NH-(m-PEG4)2
• CAS No.: 123852-08-4
• Molecular Formula: C18H39NO8
• Molecular Weight: 397.50400
• Mol file: 123852-08-4.mol

Synonyms:N,N-bis(tetraoxyethylenemonomethyl ether)amine;N,N-bis(tetraethyleneglycol-monomethylether)amine;bis-[2-[2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy]-ethyl]-amine;2,5,8,11-Tetraoxatridecan-13-amine,N-3,6,9,12-tetraoxatridec-1-yl;

Chemical Property of NH-(m-PEG4)2

Chemical Property:

• PSA: 85.87000
• LogP: 0.35930
• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

99.90% ^*data from raw suppliers

NH-(mPEG4)2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: NH-bis(m-PEG4) is a PEG building block containing an amino (NH2) group to be reactive with carboxylic acids or activated NHS esters, carbonyls.

Technology Process of NH-(m-PEG4)2

There total 7 articles about NH-(m-PEG4)2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N,N bis(tetraethyleneglycol-monomethylether)tritylamine (133531-78-9) → N,N-bis(tetraethyleneglycol-monomethylether)amine (123852-08-4)

Guidance literature:

With hydrogen cation;

DOI:10.1039/c39870001437

Reference yield: 73.0%

1-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}-2-methoxyethane (606130-90-9,89485-61-0) → N,N-bis(tetraethyleneglycol-monomethylether)amine (123852-08-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

DOI:10.1021/acs.joc.0c00331

Reference yield:

triethylene glucol monomethyl ether (112-35-6,95507-80-5) → N,N-bis(tetraethyleneglycol-monomethylether)amine (123852-08-4)

Guidance literature:

Multi-step reaction with 3 steps

2: 85 percent / KOH / tetrahydrofuran / Heating

3: 96 percent / H⁽¹⁺⁾

With potassium hydroxide; hydrogen cation; In tetrahydrofuran;

DOI:10.1039/c39870001437

upstream raw materials:

N,N bis(tetraethyleneglycol-monomethylether)tritylamine

triethylene glucol monomethyl ether

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate

8-methoxy-1-(methylsulfonyl)oxy-3,6-dioxaoctane

Refernces

• 1、 -. "SHORT CHAIN PEGYLATION OF AMINO ACID MONOMERS GLUTAMINE AND LYSINE AND PEPTIDES FORMED THEREBY". Paragraph 0044. . Retrieved 2016/01/01.
• 2、 Selve, Claude,Moumni, El Mostafa,Delpuech, Jean-Jacques. "Synthesis of Novel Perfluoroalkyl Nonionic Surfactants with a Bipodal Hydrophilic Moiety". . p. 1437 - 1438. Retrieved 2007/10/02.