(R)-ETHYL 2-AZIDOPROPANOATE

Base Information

• Chemical Name: (R)-ETHYL 2-AZIDOPROPANOATE
• CAS No.: 124988-44-9
• Molecular Formula: C5H9N3O2
• Molecular Weight: 143.145
• Mol file: 124988-44-9.mol

Synonyms:(R)-ETHYL 2-AZIDOPROPANOATE

Chemical Property of (R)-ETHYL 2-AZIDOPROPANOATE

Chemical Property:

• Boiling Point: 105 - 110 °C (100 mmHg)
• PSA: 76.05000
• LogP: 0.70106

Purity/Quality:

99.90% ^*data from raw suppliers

(R)-ETHYL-2-AZIDOPROPANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-ETHYL 2-AZIDOPROPANOATE

There total 5 articles about (R)-ETHYL 2-AZIDOPROPANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(S)-ethyl 2-(methylsulfonyloxy)propanoate (63696-99-1) → ethyl (R)-2-azidopropionate (124988-44-9)

Guidance literature:

With trimethylsilylazide; cesium fluoride; In N,N-dimethyl-formamide; at 40 ℃; for 12h;

DOI:10.1016/S0040-4020(97)00900-9

Reference yield: 87.0%

(S)-Ethyl lactate (687-47-8) → ethyl (R)-2-azidopropionate (124988-44-9)

Guidance literature:

With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jo00074a008

Reference yield: 85.0%

R(-)-octyl tosylate (27770-99-6) → ethyl (R)-2-azidopropionate (124988-44-9)

Guidance literature:

With trimethylsilylazide; cesium fluoride; In N,N-dimethyl-formamide; at 50 ℃; for 42h;

DOI:10.1016/S0040-4020(97)00900-9

upstream raw materials:

(S)-Ethyl lactate

R(-)-octyl tosylate

ethyl (S)-2-[[(4-methylphenyl)sulfonyl]oxy]propanoate

(S)-ethyl 2-(methylsulfonyloxy)propanoate

Downstream raw materials:

C₈H₁₆N₂O₃

(3S,6R)-3,6-dimethylpiperazine-2,5-dione