3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Base Information

Chemical Name:3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
CAS No.:125313-60-2
Molecular Formula:C24H21N3O3
Molecular Weight:399.44200
Hs Code.:
Mol file:125313-60-2.mol

Synonyms:3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;

Suppliers and Price of 3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
100mg
$ 1100.00

Medical Isotopes, Inc.
3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
10 mg
$ 625.00

Total 4 raw suppliers

Chemical Property of 3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Chemical Property:

Boiling Point:716.2±60.0 °C(Predicted)
PKA:7.91±0.60(Predicted)
PSA：76.26000
Density:1.36±0.1 g/cm3(Predicted)
LogP:3.41140
Storage Temp.:Refrigerator

Purity/Quality:

99.90% ^*data from raw suppliers

3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione is a Bisindolylmaleimides with protein kinase C inhibitor activity.

Technology Process of 3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

There total 4 articles about 3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 125314-97-8
3-<1-(3-acetoxypropyl)-3-indolyl>-4-(1-methyl-3-indolyl)-2,5-furandione

: 125313-60-2
3-[1-(3-hydroxy-propyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione

Guidance literature:: With ammonium hydroxide; In N,N-dimethyl-formamide; at 140 ℃; for 4h;
DOI:10.1021/jm00084a004

Reference yield:

: 120-72-9
indole

: 125313-60-2
3-[1-(3-hydroxy-propyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 0.5 h, 2.) DMF, RT, 18 h

2: CH₂Cl₂ / 3 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

4: 94 percent / 33percent aq. ammonia / dimethylformamide / 4 h / 140 °C

With ammonium hydroxide; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00084a004

Reference yield:

: 125314-98-9
N-(3-acetoxypropyl)-indole

: 125313-60-2
3-[1-(3-hydroxy-propyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 3 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

3: 94 percent / 33percent aq. ammonia / dimethylformamide / 4 h / 140 °C

With ammonium hydroxide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00084a004