1,2-Piperidinedicarboxylic acid, 4-oxo-, 1-(1,1-diMethylethyl) 2-ethyl ester

Base Information

• Chemical Name: 1,2-Piperidinedicarboxylic acid, 4-oxo-, 1-(1,1-diMethylethyl) 2-ethyl ester
• CAS No.: 125545-98-4
• Molecular Formula: C13H21NO5
• Molecular Weight: 271.31000
• Mol file: 125545-98-4.mol

Synonyms:ethyl 4-oxo-N-t-butoxycarbonyl-2-piperidinecarboxylate;1-TERT-BUTYL 2-ETHYL 4-OXOPIPERIDINE-1,2-DICARBOXYLATE;ethyl 4-oxo-N-(tert-butoxycarbonyl)piperidine-2-carboxylate;

Chemical Property of 1,2-Piperidinedicarboxylic acid, 4-oxo-, 1-(1,1-diMethylethyl) 2-ethyl ester

Chemical Property:

• PSA: 72.91000
• LogP: 1.45600

Purity/Quality:

99.99%HPLC ^*data from raw suppliers

1-(tert-Butyl) 2-ethyl 4-oxo-1,2-piperidinedicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-Piperidinedicarboxylic acid, 4-oxo-, 1-(1,1-diMethylethyl) 2-ethyl ester

There total 8 articles about 1,2-Piperidinedicarboxylic acid, 4-oxo-, 1-(1,1-diMethylethyl) 2-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 4-hydroxy-N-(tert-butoxycarbonyl)piperidine-2-carboxylate (129919-97-7,1363378-14-6) → ethyl 2SR-4-oxo-N-(t-butoxycarbonyl)piperidine-2-carboxylate (125545-98-4)

Guidance literature:

With 4 A molecular sieve; pyridinium chlorochromate; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jm00105a016

Reference yield: 79.0%

1-(tert-butoxycarbonyl)-4-oxopiperidine-2-carboxylic acid (198646-60-5,661458-35-1) → ethyl 2SR-4-oxo-N-(t-butoxycarbonyl)piperidine-2-carboxylate (125545-98-4)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.1016/j.ejmech.2021.114079

Reference yield:

ethyl cis-4-hydroxy-N-t-butoxycarbonyl-2-piperidinecarboxylate (180854-45-9,1363378-14-6) → cis-(+-)-4-[(1(2)H-Tetrazol-5-yl)methyl]-2-piperidinecarboxylic acid + ethyl 2SR-4-oxo-N-(t-butoxycarbonyl)piperidine-2-carboxylate (125545-98-4)

Guidance literature:

With pyridinium chlorochromate; In diethyl ether; dichloromethane;

upstream raw materials:

ethyl 4-hydroxy-N-(tert-butoxycarbonyl)piperidine-2-carboxylate

4-Oxo-3,4-dihydro-2H-pyridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

4-hydroxypyridine-2-carboxylic acid

ethyl 4-hydroxypyridine-2-carboxylate

Downstream raw materials:

4-[(Z)-Benzyloxyimino]-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

(2R,4R)-4-Hydroxy-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

(2R,4S)-4-Benzyloxyamino-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

(2R,4R)-4-Benzyloxyamino-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

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