Boronic acid, (2,3-difluoro-4-pentylphenyl)-

Base Information

• Chemical Name: Boronic acid, (2,3-difluoro-4-pentylphenyl)-
• CAS No.: 126334-36-9
• Molecular Formula: C11H15BF2O2
• Molecular Weight: 228.047
• Mol file: 126334-36-9.mol

Synonyms:4-n-Pentyl-2,3-difluorophenyl boronic acid;2,3-difluoro-4-pentylphenylboronic acid;2,3-difluoro-4-n-pentylphenylboronic acid;

Chemical Property of Boronic acid, (2,3-difluoro-4-pentylphenyl)-

Chemical Property:

• PSA: 40.46000
• LogP: 1.37730

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

2,3-DIFLUORO-4-PENTYLPHENYLBORONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boronic acid, (2,3-difluoro-4-pentylphenyl)-

There total 8 articles about Boronic acid, (2,3-difluoro-4-pentylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C17H27BF2O2 → 4-n-Pentyl-2,3-difluorophenyl boronic acid (126334-36-9)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 1h;

DOI:10.1039/a902351h

Reference yield: 95.4%

Trimethyl borate (121-43-7,63156-11-6) + 1,2-difluoro-3-pentylbenzene (126163-54-0) → 4-n-Pentyl-2,3-difluorophenyl boronic acid (126334-36-9)

Guidance literature:

Trimethyl borate; 1,2-difluoro-3-pentylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; Trimethyl borate; In tetrahydrofuran; hexane; water; at 20 ℃; for 3h;

Reference yield:

1,2-difluoro-3-(1-pentenyl)benzene → 4-n-Pentyl-2,3-difluorophenyl boronic acid (126334-36-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 57 percent / H₂ / 5 percent Pd/C / light petroleum / 12 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -78 °C

2.2: hexane; tetrahydrofuran / -78 - 20 °C

3.1: 98 percent / 10 percent aq. HCl / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; hydrogen; palladium on activated charcoal; In tetrahydrofuran; hexane; Petroleum ether; 1.1: Hydrogenation / 2.1: Metallation / 2.2: Substitution / 3.1: Hydrolysis;

DOI:10.1039/a902351h

upstream raw materials:

pentanal

ortho-difluorobenzene

1,2-difluoro-3-pentylbenzene

1-(2,3-difluorophenyl)pentan-1-ol

Downstream raw materials:

4-(4-(2,3-difluoro-4-pentylphenyl)phenyl)phenol

2,3-difluoro-4-heptyl-4-pentyl-p-terphenyl