2,3-Difluoro-4-heptylbenzeneboronic acid

Base Information

• Chemical Name: 2,3-Difluoro-4-heptylbenzeneboronic acid
• CAS No.: 126334-37-0
• Molecular Formula: C13H19BF2O2
• Molecular Weight: 256.1
• Mol file: 126334-37-0.mol

Synonyms:4-heptyl-2,3-difluorophenylboronic acid;2,3-DIFLUORO-4-HEPTYLPHENYL BORONIC ACID;2,3-diflouro-4-nanoylphenyl boronic acid;2,3-DIFLUORO-4-HEPTYLBENZENEBORONIC ACID;4-n-Heptyl-2,3-difluorophenyl boronic acid;

Chemical Property of 2,3-Difluoro-4-heptylbenzeneboronic acid

Chemical Property:

• PSA: 40.46000
• LogP: 2.15750

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Difluoro-4-heptylbenzeneboronic acid

There total 7 articles about 2,3-Difluoro-4-heptylbenzeneboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

heptanal (111-71-7) → 2,3-diflouro-4-nanoylphenyl boronic acid (126334-37-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C

1.2: hexane; tetrahydrofuran / -78 - 20 °C

2.1: P₂O₅ / light petroleum / 20 °C

3.1: H₂ / 5 percent Pd/C / light petroleum / 12 h / 20 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -78 °C

4.2: hexane; tetrahydrofuran / -78 - 20 °C

5.1: 10 percent aq. HCl / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; hydrogen; phosphorus pentoxide; palladium on activated charcoal; In tetrahydrofuran; hexane; Petroleum ether; 1.1: Metallation / 1.2: Addition / 2.1: Dehydration / 3.1: Hydrogenation / 4.1: Metallation / 4.2: Substitution / 5.1: Hydrolysis;

DOI:10.1039/a902351h

Reference yield:

ortho-difluorobenzene (367-11-3) → 2,3-diflouro-4-nanoylphenyl boronic acid (126334-37-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C

1.2: hexane; tetrahydrofuran / -78 - 20 °C

2.1: P₂O₅ / light petroleum / 20 °C

3.1: H₂ / 5 percent Pd/C / light petroleum / 12 h / 20 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -78 °C

4.2: hexane; tetrahydrofuran / -78 - 20 °C

5.1: 10 percent aq. HCl / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; hydrogen; phosphorus pentoxide; palladium on activated charcoal; In tetrahydrofuran; hexane; Petroleum ether; 1.1: Metallation / 1.2: Addition / 2.1: Dehydration / 3.1: Hydrogenation / 4.1: Metallation / 4.2: Substitution / 5.1: Hydrolysis;

DOI:10.1039/a902351h

Reference yield:

1-(2,3-difluorophenyl)heptan-1-ol (126334-32-5) → 2,3-diflouro-4-nanoylphenyl boronic acid (126334-37-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: P₂O₅ / light petroleum / 20 °C

2.1: H₂ / 5 percent Pd/C / light petroleum / 12 h / 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -78 °C

3.2: hexane; tetrahydrofuran / -78 - 20 °C

4.1: 10 percent aq. HCl / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; hydrogen; phosphorus pentoxide; palladium on activated charcoal; In tetrahydrofuran; hexane; Petroleum ether; 1.1: Dehydration / 2.1: Hydrogenation / 3.1: Metallation / 3.2: Substitution / 4.1: Hydrolysis;

DOI:10.1039/a902351h

upstream raw materials:

heptanal

ortho-difluorobenzene

1,2-difluoro-3-heptylbenzene

1-(2,3-difluorophenyl)heptan-1-ol

Downstream raw materials:

2,3-difluoro-4-heptyl-4-pentyl-p-terphenyl