2-[2-(2-METHOXYETHOXY)ETHOXY]PHENYLAMINE

Base Information

• Chemical Name: 2-[2-(2-METHOXYETHOXY)ETHOXY]PHENYLAMINE
• CAS No.: 126415-03-0
• Molecular Formula: C11H17NO3
• Molecular Weight: 211.25800
• Mol file: 126415-03-0.mol

Synonyms:

Chemical Property of 2-[2-(2-METHOXYETHOXY)ETHOXY]PHENYLAMINE

Chemical Property:

• PSA: 53.71000
• LogP: 1.89180

Purity/Quality:

98%min ^*data from raw suppliers

2-[2-(2-Methoxyethoxy)ethoxy]phenylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 2-[2-(2-METHOXYETHOXY)ETHOXY]PHENYLAMINE

There total 5 articles about 2-[2-(2-METHOXYETHOXY)ETHOXY]PHENYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester (50586-80-6,58320-73-3) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → 2-(2-(2-methoxyethoxy)ethoxy)benzenamine (126415-03-0)

Guidance literature:

toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester; 2-hydroxynitrobenzene; With potassium carbonate; In N,N-dimethyl-formamide; Inert atmosphere; Reflux;

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 24h;

DOI:10.1039/c7ra11414a

Reference yield: 71.0%

tert-butyl 2-(2-(2-methoxyethoxy)ethoxy)phenylcarbamate (1161412-21-0) → 2-(2-(2-methoxyethoxy)ethoxy)benzenamine (126415-03-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 40 ℃; for 3h;

DOI:10.1016/j.polymer.2011.07.052

Reference yield:

2-(2-methoxyethoxy)ethyl alcohol (111-77-3,95507-80-5) → 2-(2-(2-methoxyethoxy)ethoxy)benzenamine (126415-03-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 3 h

2.1: potassium tert-butylate / tetrahydrofuran / 40 °C / Inert atmosphere

2.2: 72.5 h / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 40 °C

With potassium tert-butylate; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.polymer.2011.07.052

upstream raw materials:

tert-butyl 2-(2-(2-methoxyethoxy)ethoxy)phenylcarbamate

2-(2-methoxyethoxy)ethyl alcohol

toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester

tert-butyl (2-hydroxyphenyl)carbamate