Cytidine, N-acetyl-2',3'-dideoxy-, 5'-[2-(acetyloxy)benzoate]

Base Information

• Chemical Name: Cytidine, N-acetyl-2',3'-dideoxy-, 5'-[2-(acetyloxy)benzoate]
• CAS No.: 126430-21-5
• Molecular Formula: C20H21N3O7
• Molecular Weight: 415.403
• Mol file: 126430-21-5.mol

Synonyms:

Chemical Property of Cytidine, N-acetyl-2',3'-dideoxy-, 5'-[2-(acetyloxy)benzoate]

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cytidine, N-acetyl-2',3'-dideoxy-, 5'-[2-(acetyloxy)benzoate]

There total 4 articles about Cytidine, N-acetyl-2',3'-dideoxy-, 5'-[2-(acetyloxy)benzoate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Acetoxy-benzoic acid (2S,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl ester (126430-19-1) → 2-Acetoxy-benzoic acid (2S,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (126430-21-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; under 760 Torr; Ambient temperature;

DOI:10.1021/jo00038a042

Reference yield:

2-Acetoxybenzoyl bromide (88803-91-2) → 2-Acetoxy-benzoic acid (2S,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (126430-21-5)

Guidance literature:

Multi-step reaction with 2 steps

2: 970 mg / H₂ / 10percent Pd/C / methanol; dimethylformamide / 760 Torr / Ambient temperature

With hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jo00038a042

Reference yield:

N-acetylcytidine (3768-18-1) → 2-Acetoxy-benzoic acid (2S,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (126430-21-5)

Guidance literature:

Multi-step reaction with 2 steps

2: 970 mg / H₂ / 10percent Pd/C / methanol; dimethylformamide / 760 Torr / Ambient temperature

With hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jo00038a042

upstream raw materials:

2-Acetoxy-benzoic acid (2S,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl ester

2-Acetoxybenzoyl bromide

N-acetylcytidine

O-acetylsalicyloyl chloride

Refernces