(S)-2-fluoro-4-methylpentanoic acid

Base Information

• Chemical Name: (S)-2-fluoro-4-methylpentanoic acid
• CAS No.: 126957-44-6
• Molecular Formula: C6H11FO2
• Molecular Weight: 134.14900
• Hs Code.: 2915601990
• Mol file: 126957-44-6.mol

Synonyms:PENTANOIC ACID, 2-FLUORO-4-METHYL-, (S)-;(2S)-2-FLUORO-4-METHYLPENTANOIC ACID;

Chemical Property of (S)-2-fluoro-4-methylpentanoic acid

Chemical Property:

• PSA: 37.30000
• LogP: 1.45520

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-fluoro-4-methylpentanoic acid

There total 2 articles about (S)-2-fluoro-4-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → (S)-2-fluoro-4-methylpentanoic acid (126957-44-6)

Guidance literature:

With pyridine hydrogenfluoride; sodium nitrite; for 6h; Ambient temperature;

Reference yield:

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → (R)-2-fluoro-4-methylpentanoic acid (146746-27-2) + (S)-2-fluoro-4-methylpentanoic acid (126957-44-6)

Guidance literature:

With pyridine hydrofluoride; sodium nitrite; at -10 - 20 ℃; for 3h; optical yield given as %ee; Inert atmosphere;

DOI:10.1002/ejoc.200900089

Reference yield:

(S)-2-fluoro-4-methylpentanoic acid (126957-44-6) → 2'-<6'-((2''S-2''-fluoro-4''-methylpentanoyl)oxy)>naphthyl 4-decyloxybenzoate (143238-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / benzene / Heating

2: Et₃N / CHCl₃ / 5 h / Ambient temperature

With thionyl chloride; triethylamine; In chloroform; benzene;

upstream raw materials:

L-leucine

Downstream raw materials:

2'-<6'-((2''S-2''-fluoro-4''-methylpentanoyl)oxy)>naphthyl 4-decyloxybenzoate

Refernces

• 1、 Sierra,Serrano,Ros,Ezcurra,Zubía. "Synthesis and study of new α-haloacid ferroelectric liquid crystal derivatives. MM2 approach to the molecular structure-ferroelectric activity relationship". . p. 7645 - 7651. Retrieved 2007/10/02.