3,3-Dimethylpyrrolidine-2-thione

Base Information

• Chemical Name: 3,3-Dimethylpyrrolidine-2-thione
• CAS No.: 127103-83-7
• Molecular Formula: C6H11NS
• Molecular Weight: 129.22300
• Mol file: 127103-83-7.mol

Synonyms:3,3-dimethyl-2-thio-pyrrolidinone;2-Pyrrolidinethione,3,3-dimethyl;

Chemical Property of 3,3-Dimethylpyrrolidine-2-thione

Chemical Property:

• PSA: 51.16000
• LogP: 1.18020

Purity/Quality:

98%min ^*data from raw suppliers

3,3-dimethylpyrrolidine-2-thione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3-Dimethylpyrrolidine-2-thione

There total 2 articles about 3,3-Dimethylpyrrolidine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3,3-dimethylpyrrolidin-2-one (4831-43-0) → 3,3-dimethylpyrrolidine-2-thione (127103-83-7)

Guidance literature:

With Lawessons reagent; In toluene; for 0.5h; Heating;

DOI:10.3987/COM-93-S(B)16 DOI:10.3987/COM-93-S(B)16-1

Reference yield:

4-Isothiocyanato-2-methyl-but-1-ene (13009-49-9) → 3,3-dimethylpyrrolidine-2-thione (127103-83-7)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); water; tri-n-butyl-tin hydride; Yield given. Multistep reaction; 1.) toluene, 75 deg C 2.) SiO₂;

DOI:10.1021/jo00298a008

Reference yield: 96.0%

(chlorocarbonyl)phenyl ketene (17118-70-6) + 3,3-dimethylpyrrolidine-2-thione (127103-83-7) → anhydro-8,8-dimethyl-4-hydroxy-2-oxo-3-phenyl-7,8-dihydropyrrolo<2,1-b><1,3>thiazinium hydroxide

Guidance literature:

In dichloromethane; for 0.166667h; Ambient temperature;

DOI:10.1016/0040-4020(95)00323-Z

upstream raw materials:

4-Isothiocyanato-2-methyl-but-1-ene

3,3-dimethylpyrrolidin-2-one

Downstream raw materials:

8,8-dimethyl-2-phenyl-7,8-dihydro-6H-2,5a-diazo-as-indacene-1,3,5-trione

Refernces

• 1、 Padwa, Albert,Coats, Steven J.,Hadjiarapoglou, Lazaros. "8H-Anhydro-4-hydroxy-2-oxo-1,3-thiazinium Hydroxides as mesoionic 1,4-Dipoles". . p. 219 - 242. Retrieved 2007/10/02.