2-cyano-3-[5-(2-nitrophenyl)furan-2-yl]-N-(2,4,6-trimethylphenyl)prop-2-enamide

Base Information

Chemical Name:2-cyano-3-[5-(2-nitrophenyl)furan-2-yl]-N-(2,4,6-trimethylphenyl)prop-2-enamide
CAS No.:5273-96-1
Molecular Formula:C23H19N3O4
Molecular Weight:208.257
Hs Code.:
DSSTox Substance ID:DTXSID30360861
Mol file:5273-96-1.mol

Synonyms:5273-96-1;DTXSID30360861;2-cyano-3-[5-(2-nitrophenyl)furan-2-yl]-N-(2,4,6-trimethylphenyl)prop-2-enamide

Suppliers and Price of 2-cyano-3-[5-(2-nitrophenyl)furan-2-yl]-N-(2,4,6-trimethylphenyl)prop-2-enamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-cyano-3-[5-(2-nitrophenyl)furan-2-yl]-N-(2,4,6-trimethylphenyl)prop-2-enamide

Chemical Property:

Vapor Pressure:2.55E-15mmHg at 25°C
Boiling Point:620.5°Cat760mmHg
Flash Point:329°C
Density:1.295g/cm³
XLogP3:5.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:401.13755610
Heavy Atom Count:30
Complexity:710

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C(=C1)C)NC(=O)C(=CC2=CC=C(O2)C3=CC=CC=C3[N+](=O)[O-])C#N)C

Technology Process of 2-cyano-3-[5-(2-nitrophenyl)furan-2-yl]-N-(2,4,6-trimethylphenyl)prop-2-enamide

There total 8 articles about 2-cyano-3-[5-(2-nitrophenyl)furan-2-yl]-N-(2,4,6-trimethylphenyl)prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 834-93-5
1,3,5-trimethoxy-2-(1-hydroxypropyl)benzene

: 5273-96-1
(E)-1,3,5-trimethoxy-2-(prop-1-en-1-yl)benzene

Guidance literature:: With silica gel; In 1,4-dioxane; for 0.05h; microwave irradiation;
DOI:10.1246/bcsj.77.2231

Reference yield: 60.7%

: 830-79-5
2,4,6-trimethoxybenzaldehyde

: 1530-32-1
ethyltriphenylphosphonium bromide

: 5273-96-1
(E)-1,3,5-trimethoxy-2-(prop-1-en-1-yl)benzene

Guidance literature:: With potassium tert-butylate; tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 0 - 95 ℃; for 4.5h; Inert atmosphere;
DOI:10.1016/j.bioorg.2021.105179

Reference yield:

: 830-79-5
2,4,6-trimethoxybenzaldehyde

: 5273-96-1
(E)-1,3,5-trimethoxy-2-(prop-1-en-1-yl)benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / diethyl ether / 2 h

1.2: 81 percent / diethyl ether; toluene / 20 °C

2.1: 64 percent / silica gel / dioxane / 0.05 h / microwave irradiation

With silica gel; magnesium; In 1,4-dioxane; diethyl ether; 1.2: Grignard reaction;
DOI:10.1246/bcsj.77.2231