Tetrakis(2-propynyloxymethyl) methane

Base Information

• Chemical Name: Tetrakis(2-propynyloxymethyl) methane
• CAS No.: 127751-08-0
• Molecular Formula: C17H20O4
• Molecular Weight: 288.343
• Mol file: 127751-08-0.mol

Synonyms:TETRAKIS(2-PROPYNYLOXYMETHYL) METHANE;

Chemical Property of Tetrakis(2-propynyloxymethyl) methane

Chemical Property:

• Melting Point: >47°C (dec.)
• PSA: 36.92000
• LogP: 0.57200
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly, Sonicated)

Purity/Quality:

99.90% ^*data from raw suppliers

Tetrakis(2-propynyloxymethyl)methane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Tetrakis(2-propynyloxymethyl)methane is used in preparation of Aminoglycoside Cyclic Oligosaccharides as Multimeric P- and E-selectin antagonists.

Technology Process of Tetrakis(2-propynyloxymethyl) methane

There total 5 articles about Tetrakis(2-propynyloxymethyl) methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.8%

Pentaerythritol (115-77-5) + propargyl bromide (106-96-7) → tetrakis(prop-2ynyloxymethyl)methane (127751-08-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 40 - 50 ℃; for 19h; Cooling;

Reference yield: 87.0%

Pentaerythritol (115-77-5) + 2-propynyl chloride (624-65-7) → tetrakis(prop-2ynyloxymethyl)methane (127751-08-0)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 25 - 35 ℃; or with propargyl bromide at 25 - 26 deg C;

Reference yield: 71.0%

Pentaerythritol (115-77-5) + propargyl bromide (106-96-7) → tetrakis(prop-2ynyloxymethyl)methane (127751-08-0) + 3-(prop-2-yn-1-yloxy)-2,2-bis((prop-2-yn-1-yloxy)methyl)propan-1-ol (292601-30-0)

Guidance literature:

With sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 24h;

DOI:10.1021/ol006175v

upstream raw materials:

Pentaerythritol

2-propynyl chloride

propargyl bromide

Downstream raw materials:

C₁₀₅H₁₄₄N₂₀O₄₀