Diethyl [1-amino-2-(4-methoxyphenyl)ethyl]phosphonate

Base Information

• Chemical Name: Diethyl [1-amino-2-(4-methoxyphenyl)ethyl]phosphonate
• CAS No.: 127780-65-8
• Molecular Formula: C13H22NO4P
• Molecular Weight: 287.296
• DSSTox Substance ID: DTXSID00565245
• Nikkaji Number: J282.093E
• Mol file: 127780-65-8.mol

Synonyms:127780-65-8;Diethyl [1-amino-2-(4-methoxyphenyl)ethyl]phosphonate;DTXSID00565245

Chemical Property of Diethyl [1-amino-2-(4-methoxyphenyl)ethyl]phosphonate

Chemical Property:

• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 287.12864518
• Heavy Atom Count: 19
• Complexity: 282

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOP(=O)(C(CC1=CC=C(C=C1)OC)N)OCC

Technology Process of Diethyl [1-amino-2-(4-methoxyphenyl)ethyl]phosphonate

There total 9 articles about Diethyl [1-amino-2-(4-methoxyphenyl)ethyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

O,O-diethyl-1-oximato-2-(4-methoxyphenyl)-ethylphosphonate (137619-23-9) → <1-Amino-2-(4-methoxy)phenyl>ethylphosphonate de diethyle (127780-65-8)

Guidance literature:

With hydrogen; nickel; In ethanol; at 100 ℃; for 6h; under 60004.8 Torr;

Reference yield: 55.0%

[1-(Benzhydrylidene-amino)-2-(4-methoxy-phenyl)-ethyl]-phosphonic acid diethyl ester (127780-59-0) → <1-Amino-2-(4-methoxy)phenyl>ethylphosphonate de diethyle (127780-65-8)

Guidance literature:

With hydrogenchloride; potassium carbonate; In diethyl ether; dichloromethane; Ambient temperature;

DOI:10.1055/s-1990-26782

Reference yield: 23.0%

(2-(4-Methoxy-phenyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-ethyl)-phosphonic acid diethyl ester (130828-97-6) → <1-Amino-2-(4-methoxy)phenyl>ethylphosphonate de diethyle (127780-65-8)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In isopropyl alcohol; at 20 - 25 ℃; for 19h;

upstream raw materials:

[1-(Benzhydrylidene-amino)-2-(4-methoxy-phenyl)-ethyl]-phosphonic acid diethyl ester

(2-(4-Methoxy-phenyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-ethyl)-phosphonic acid diethyl ester

O,O-diethyl-1-oximato-2-(4-methoxyphenyl)-ethylphosphonate

<1-Isocyanato(2(4-methoxy)phenyl)>ethylphosphonate de diethyle

Downstream raw materials:

1-amino-2-(4-hydroxyphenyl)ethylphosphonic acid

1-amino-2-(4-methoxyphenyl)-ethylphosphonic acid

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