[2-(2,6-Dichloro-3-methoxyanilino)phenyl]acetic acid

Base Information

Chemical Name:[2-(2,6-Dichloro-3-methoxyanilino)phenyl]acetic acid
CAS No.:127792-26-1
Molecular Formula:C₁₅H₁₃Cl₂NO₃
Molecular Weight:326.179
Hs Code.:
ChEMBL ID:CHEMBL76300
DSSTox Substance ID:DTXSID20563748
Nikkaji Number:J341.686K
Wikidata:Q82448227
Mol file:127792-26-1.mol

Synonyms:CHEMBL76300;127792-26-1;[2-(2,6-Dichloro-3-methoxyanilino)phenyl]acetic acid;SCHEMBL7166342;DTXSID20563748;BDBM50228748

Suppliers and Price of [2-(2,6-Dichloro-3-methoxyanilino)phenyl]acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of [2-(2,6-Dichloro-3-methoxyanilino)phenyl]acetic acid

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:325.0272487
Heavy Atom Count:21
Complexity:356

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C(=C(C=C1)Cl)NC2=CC=CC=C2CC(=O)O)Cl

Technology Process of [2-(2,6-Dichloro-3-methoxyanilino)phenyl]acetic acid

There total 4 articles about [2-(2,6-Dichloro-3-methoxyanilino)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [2-(2,6-Dichloro-3-methoxy-phenylamino)-phenyl]-oxo-acetic acid

: 127792-26-1
[2-(2,6-Dichloro-3-methoxy-phenylamino)-phenyl]-acetic acid

Guidance literature:: With sodium methylate; hydrazine hydrate; In 2-methoxy-ethanol; Yield given; 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h;
DOI:10.1021/jm00171a008

Reference yield:

: 1618-54-8
(2,6-Dichloro-3-methoxy-phenyl)-phenyl-amine

: 127792-26-1
[2-(2,6-Dichloro-3-methoxy-phenylamino)-phenyl]-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: benzene / 2 h / Ambient temperature

2: AlCl₃ / various solvent(s) / 20 h / Ambient temperature

3: 1 N NaOH / ethanol; H₂O / 0.17 h / Heating

4: hydrazine hydrate, NaOCH₃ / 2-methoxy-ethanol / 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h

With sodium hydroxide; aluminium trichloride; sodium methylate; hydrazine hydrate; In ethanol; 2-methoxy-ethanol; water; benzene;
DOI:10.1021/jm00171a008

Reference yield:

: 1-(2,6-Dichloro-3-methoxy-phenyl)-1H-indole-2,3-dione

: 127792-26-1
[2-(2,6-Dichloro-3-methoxy-phenylamino)-phenyl]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1 N NaOH / ethanol; H₂O / 0.17 h / Heating

2: hydrazine hydrate, NaOCH₃ / 2-methoxy-ethanol / 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h

With sodium hydroxide; sodium methylate; hydrazine hydrate; In ethanol; 2-methoxy-ethanol; water;
DOI:10.1021/jm00171a008